Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD)

Celion Tang; Hitesh Mistry; Neil Bayman; Clara Chan; David Cobben; Corinne Faivre-Finn; Margaret Harris; Jason Kennedy; Laura Pemberton; Gareth Price; Hamid Sheikh; David Woolf; Joanna Coote; Ahmed Salem

doi:10.1016/j.radonc.2021.04.014

Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD)

Celion Tang, Hitesh Mistry, Neil Bayman, Clara Chan, David Cobben, Corinne Faivre-Finn, Margaret Harris, Jason Kennedy, Laura Pemberton, Gareth Price, Hamid Sheikh, David Woolf, Joanna Coote, Ahmed Salem

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Abstract

Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.

Original language	English
Pages (from-to)	78-81
Number of pages	4
Journal	Radiotherapy and Oncology
Volume	160
Early online date	23 Apr 2021
DOIs	https://doi.org/10.1016/j.radonc.2021.04.014
Publication status	Published - 1 Jul 2021

Keywords

COPD
FEV1
ILD
NSCLC
Radiotherapy
Survival

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.radonc.2021.04.014

Manuscript 2_cleanAccepted author manuscript, 122 KBLicence: CC BY-NC-ND

Cite this

Tang, C., Mistry, H., Bayman, N., Chan, C., Cobben, D., Faivre-Finn, C., Harris, M., Kennedy, J., Pemberton, L., Price, G., Sheikh, H., Woolf, D., Coote, J., & Salem, A. (2021). Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Radiotherapy and Oncology, 160, 78-81. https://doi.org/10.1016/j.radonc.2021.04.014

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title = "Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD)",

abstract = "Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.",

keywords = "COPD, FEV1, ILD, NSCLC, Radiotherapy, Survival",

author = "Celion Tang and Hitesh Mistry and Neil Bayman and Clara Chan and David Cobben and Corinne Faivre-Finn and Margaret Harris and Jason Kennedy and Laura Pemberton and Gareth Price and Hamid Sheikh and David Woolf and Joanna Coote and Ahmed Salem",

note = "Funding Information: This study was supported by researchers at the NIHR Manchester Biomedical Research Centre (C. Faivre-Finn). A. Salem is supported by the Manchester Cancer Research Centre, The Christie Charity and by a University of Manchester Presidential Fellowship for Clinicians. This work was supported by Cancer Research UK via the funding to Cancer Research UK Manchester Centre: (C147/A18083) and (C147/A25254). Funding Information: C. Faivre-Finn has declared research grants from AstraZeneca, MSD and Elekta and sits on the advisory boards of AstraZeneca and Pfizer. D. Woolf has declared travel grants, consultancy and speaker fees from AstraZeneca and travel grants from Roche. None of the other co-authors have any relevant conflicts of interest. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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doi = "10.1016/j.radonc.2021.04.014",

language = "English",

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Tang, C, Mistry, H, Bayman, N, Chan, C, Cobben, D, Faivre-Finn, C, Harris, M, Kennedy, J, Pemberton, L, Price, G, Sheikh, H, Woolf, D, Coote, J & Salem, A 2021, 'Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD)', Radiotherapy and Oncology, vol. 160, pp. 78-81. https://doi.org/10.1016/j.radonc.2021.04.014

TY - JOUR

T1 - Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD)

AU - Tang, Celion

AU - Mistry, Hitesh

AU - Bayman, Neil

AU - Chan, Clara

AU - Cobben, David

AU - Faivre-Finn, Corinne

AU - Harris, Margaret

AU - Kennedy, Jason

AU - Pemberton, Laura

AU - Price, Gareth

AU - Sheikh, Hamid

AU - Woolf, David

AU - Coote, Joanna

AU - Salem, Ahmed

N1 - Funding Information: This study was supported by researchers at the NIHR Manchester Biomedical Research Centre (C. Faivre-Finn). A. Salem is supported by the Manchester Cancer Research Centre, The Christie Charity and by a University of Manchester Presidential Fellowship for Clinicians. This work was supported by Cancer Research UK via the funding to Cancer Research UK Manchester Centre: (C147/A18083) and (C147/A25254). Funding Information: C. Faivre-Finn has declared research grants from AstraZeneca, MSD and Elekta and sits on the advisory boards of AstraZeneca and Pfizer. D. Woolf has declared travel grants, consultancy and speaker fees from AstraZeneca and travel grants from Roche. None of the other co-authors have any relevant conflicts of interest. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.

AB - Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.

KW - COPD

KW - FEV1

KW - ILD

KW - NSCLC

KW - Radiotherapy

KW - Survival

U2 - 10.1016/j.radonc.2021.04.014

DO - 10.1016/j.radonc.2021.04.014

M3 - Article

SN - 0167-8140

VL - 160

SP - 78

EP - 81

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

ER -

Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD)

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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