Abstract
Introduction: The objective was to identify and summarize the outcomes and evaluation methods used in clinical trials regarding the prevention and treatment of orthodontically induced white spot lesions (WSLs).
Methods: Three electronic databases were searched to identify studies that were: 1) clinical trials on prevention and/or treatment of orthodontically induced WSLs; 2) reported in English; and 3) published between January 2010 and October 2019. At least two authors assessed the eligibility and extracted the characteristics, outcomes and evaluation methods used from included studies. All disagreements were resolved through discussion.
Results: Among 1328 studies identified, 51 were eligible and included. A total of 48 different outcomes and 11 different evaluation methods were used in these studies. The most frequently used outcomes were WSLs clinical visual examination scores (n=22, 43.1%), DIAGNOdent values (n=14, 27.5%), fluorescence loss measured with quantitative light-induced fluorescence (QLF) (n=10, 19.6%), and lesion area measured with QLF (n=10, 19.6%). The most frequently used evaluation methods were clinical examination (n=25, 49.0%), visual inspection by photographs (n=15, 29.4%), DIAGNOdent (n=14, 27.5%), and QLF (n=10, 19.6%). None of the included studies reported data on quality of life.
Conclusion: Substantial outcome heterogeneity exists among studies regarding prevention and treatment of orthodontically induced WSLs. Most of the identified outcomes are aimed to assess morphologic changes of WSLs and may not reflect patient perspectives.
Methods: Three electronic databases were searched to identify studies that were: 1) clinical trials on prevention and/or treatment of orthodontically induced WSLs; 2) reported in English; and 3) published between January 2010 and October 2019. At least two authors assessed the eligibility and extracted the characteristics, outcomes and evaluation methods used from included studies. All disagreements were resolved through discussion.
Results: Among 1328 studies identified, 51 were eligible and included. A total of 48 different outcomes and 11 different evaluation methods were used in these studies. The most frequently used outcomes were WSLs clinical visual examination scores (n=22, 43.1%), DIAGNOdent values (n=14, 27.5%), fluorescence loss measured with quantitative light-induced fluorescence (QLF) (n=10, 19.6%), and lesion area measured with QLF (n=10, 19.6%). The most frequently used evaluation methods were clinical examination (n=25, 49.0%), visual inspection by photographs (n=15, 29.4%), DIAGNOdent (n=14, 27.5%), and QLF (n=10, 19.6%). None of the included studies reported data on quality of life.
Conclusion: Substantial outcome heterogeneity exists among studies regarding prevention and treatment of orthodontically induced WSLs. Most of the identified outcomes are aimed to assess morphologic changes of WSLs and may not reflect patient perspectives.
| Original language | English |
|---|---|
| Journal | American Journal of Orthodontics and Dentofacial Orthopedics |
| Publication status | Accepted/In press - 4 May 2021 |