Outer membrane translocons: Structural insights into channel formation

Vijaykumar Karuppiah, Jamie Lee Berry, Jeremy P. Derrick

    Research output: Contribution to journalArticlepeer-review


    Gram-negative bacteria need to maintain the integrity of their outer membrane while also regulating the secretion of toxins and other macromolecules. A variety of dedicated outer membrane proteins (OMPs) facilitate this process. Recent structural work has shown that some of these proteins adopt classical β-barrel transmembrane structures and rely on structural changes within the barrel lumen to allow passage of substrate proteins. Other secretion systems have OMP components which use transmembrane α-helices and appear to function in a different way. Here we review a selection of recent structural studies which have major ramifications for our understanding of the passage of macromolecules across the outer membrane. © 2010 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)40-48
    Number of pages8
    JournalTrends in Microbiology
    Issue number1
    Publication statusPublished - Jan 2011


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