Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection

Graham R. Stewart; Valerie A. Snewin; Gerhard Walzl; Tracy Hussell; Peter Tormay; Peadar O'Gaora; Madhu Goyal; Joanna Betts; Ivor N. Brown; Douglas B. Young

doi:10.1038/89113

Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection

Graham R. Stewart, Valerie A. Snewin, Gerhard Walzl, Tracy Hussell, Peter Tormay, Peadar O'Gaora, Madhu Goyal, Joanna Betts, Ivor N. Brown, Douglas B. Young

Research output: Contribution to journal › Article › peer-review

Abstract

Elevated expression of heat-shock proteins (HSPs) can benefit a microbial pathogen struggling to penetrate host defenses during infection, but at the same time might provide a crucial signal alerting the host immune system to its presence. To determine which of these effects predominate, we constructed a mutant strain of Mycobacterium tuberculosis that constitutively overexpresses Hsp70 proteins. Although the mutant was fully virulent in the initial stage of infection, it was significantly impaired in its ability to persist during the subsequent chronic phase. Induction of microbial genes encoding HSPs might provide a novel strategy to boost the immune response of individuals with latent tuberculosis infection.

Original language	English
Pages (from-to)	732-737
Number of pages	5
Journal	Nature Medicine
Volume	7
Issue number	6
DOIs	https://doi.org/10.1038/89113
Publication status	Published - 2001

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10.1038/89113

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title = "Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection",

abstract = "Elevated expression of heat-shock proteins (HSPs) can benefit a microbial pathogen struggling to penetrate host defenses during infection, but at the same time might provide a crucial signal alerting the host immune system to its presence. To determine which of these effects predominate, we constructed a mutant strain of Mycobacterium tuberculosis that constitutively overexpresses Hsp70 proteins. Although the mutant was fully virulent in the initial stage of infection, it was significantly impaired in its ability to persist during the subsequent chronic phase. Induction of microbial genes encoding HSPs might provide a novel strategy to boost the immune response of individuals with latent tuberculosis infection.",

author = "Stewart, {Graham R.} and Snewin, {Valerie A.} and Gerhard Walzl and Tracy Hussell and Peter Tormay and Peadar O'Gaora and Madhu Goyal and Joanna Betts and Brown, {Ivor N.} and Young, {Douglas B.}",

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AU - Stewart, Graham R.

AU - Snewin, Valerie A.

AU - Walzl, Gerhard

AU - Hussell, Tracy

AU - Tormay, Peter

AU - O'Gaora, Peadar

AU - Goyal, Madhu

AU - Betts, Joanna

AU - Brown, Ivor N.

AU - Young, Douglas B.

PY - 2001

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AB - Elevated expression of heat-shock proteins (HSPs) can benefit a microbial pathogen struggling to penetrate host defenses during infection, but at the same time might provide a crucial signal alerting the host immune system to its presence. To determine which of these effects predominate, we constructed a mutant strain of Mycobacterium tuberculosis that constitutively overexpresses Hsp70 proteins. Although the mutant was fully virulent in the initial stage of infection, it was significantly impaired in its ability to persist during the subsequent chronic phase. Induction of microbial genes encoding HSPs might provide a novel strategy to boost the immune response of individuals with latent tuberculosis infection.

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JO - Nature Medicine

JF - Nature Medicine

IS - 6

ER -

Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection

Abstract

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