TY - JOUR
T1 - Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea
AU - Kunos, L.
AU - Lazar, Z.
AU - Martinovszky, F.
AU - Tarnoki, A.D.
AU - Tarnoki, D.L.
AU - Kovacs, D.
AU - Forgo, B.
AU - Horvath, P.
AU - Losonczy, G.
AU - Bikov, A.
N1 - Cited By :5
Export Date: 31 October 2018
CODEN: LUNGD
Correspondence Address: Bikov, A.; Department of Pulmonology, Semmelweis University, 1/C Dios arok, Hungary; email: [email protected]
Chemicals/CAS: Adrenergic beta-Antagonists; Hydroxymethylglutaryl-CoA Reductase Inhibitors
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PY - 2017
Y1 - 2017
N2 - Purpose: Obstructive sleep apnoea (OSA) is a prevalent disorder, characterised by collapse of the upper airways during sleep. The impact of sleep-disordered breathing on pulmonary function indices is however currently not well described. The aim of the study was to evaluate diurnal change in lung function indices in a cohort of patients with OSA and relate pulmonary function changes to disease severity. Methods: 42 patients with OSA and 73 healthy control subjects participated in the study. Asthma and COPD were excluded in all volunteers following a clinical and spirometric assessment. Spirometry was then performed in all subjects in the evening and the morning following a polysomnography study. Results: There was no difference in evening or morning FEV1 or FVC between patients and control subjects (p > 0.05). Neither FEV1 nor FVC changed in control subjects overnight (p > 0.05). In contrast, FEV1 significantly increased from evening (2.18/1.54–4.46/L) to morning measurement (2.26/1.42–4.63/L) in OSA without any change in FVC. The FEV1 increase in OSA was related to male gender, obesity and the lack of treatment with statins or β-blockers (all p < 0.05). A tendency for a direct correlation was apparent between overnight FEV1 change and RDI (p = 0.05, r = 0.30). Conclusions: Diurnal variations in spirometric indices occur in patients with OSA and FEV1 appears to increase in subjects with OSA overnight. These changes occur in the absence of change in FVC and are directly related to the severity of OSA. These findings dictate a need to consider time of lung function measurement. © 2016, Springer Science+Business Media New York.
AB - Purpose: Obstructive sleep apnoea (OSA) is a prevalent disorder, characterised by collapse of the upper airways during sleep. The impact of sleep-disordered breathing on pulmonary function indices is however currently not well described. The aim of the study was to evaluate diurnal change in lung function indices in a cohort of patients with OSA and relate pulmonary function changes to disease severity. Methods: 42 patients with OSA and 73 healthy control subjects participated in the study. Asthma and COPD were excluded in all volunteers following a clinical and spirometric assessment. Spirometry was then performed in all subjects in the evening and the morning following a polysomnography study. Results: There was no difference in evening or morning FEV1 or FVC between patients and control subjects (p > 0.05). Neither FEV1 nor FVC changed in control subjects overnight (p > 0.05). In contrast, FEV1 significantly increased from evening (2.18/1.54–4.46/L) to morning measurement (2.26/1.42–4.63/L) in OSA without any change in FVC. The FEV1 increase in OSA was related to male gender, obesity and the lack of treatment with statins or β-blockers (all p < 0.05). A tendency for a direct correlation was apparent between overnight FEV1 change and RDI (p = 0.05, r = 0.30). Conclusions: Diurnal variations in spirometric indices occur in patients with OSA and FEV1 appears to increase in subjects with OSA overnight. These changes occur in the absence of change in FVC and are directly related to the severity of OSA. These findings dictate a need to consider time of lung function measurement. © 2016, Springer Science+Business Media New York.
KW - Forced expiratory volume in 1 s
KW - Lung function
KW - Obstructive sleep apnoea
KW - Overnight changes
KW - angiotensin receptor antagonist
KW - beta adrenergic receptor blocking agent
KW - calcium channel blocking agent
KW - dipeptidyl carboxypeptidase inhibitor
KW - hydroxymethylglutaryl coenzyme A reductase inhibitor
KW - adult
KW - aged
KW - Article
KW - blood pressure
KW - clinical article
KW - comorbidity
KW - controlled study
KW - disease severity
KW - Epworth sleepiness scale
KW - female
KW - forced expiratory volume
KW - forced vital capacity
KW - heart rate
KW - human
KW - lung function
KW - lung volume
KW - male
KW - obesity
KW - polysomnography
KW - priority journal
KW - sleep disordered breathing
KW - spirometry
KW - case control study
KW - complication
KW - middle aged
KW - pathophysiology
KW - severity of illness index
KW - sex difference
KW - time factor
KW - vital capacity
KW - young adult
KW - Adrenergic beta-Antagonists
KW - Adult
KW - Aged
KW - Blood Pressure
KW - Case-Control Studies
KW - Female
KW - Forced Expiratory Volume
KW - Heart Rate
KW - Humans
KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors
KW - Male
KW - Middle Aged
KW - Obesity
KW - Polysomnography
KW - Severity of Illness Index
KW - Sex Factors
KW - Sleep Apnea, Obstructive
KW - Time Factors
KW - Vital Capacity
KW - Young Adult
U2 - 10.1007/s00408-016-9957-1
DO - 10.1007/s00408-016-9957-1
M3 - Article
SN - 0341-2040
VL - 195
SP - 127
EP - 133
JO - Lung
JF - Lung
IS - 1
ER -
