Oxadiazole isomers: all bioisosteres are not created equal

Kristin Goldberg; Sam Groombridge; Julian Hudson; Andrew G. Leach; Philip A. MacFaul; Adrian Pickup; Ruth Poultney; James S. Scott; Per H. Svensson; Joseph Sweeney

doi:10.1039/c2md20054f

Oxadiazole isomers: all bioisosteres are not created equal

Kristin Goldberg, Sam Groombridge, Julian Hudson, Andrew G. Leach, Philip A. MacFaul, Adrian Pickup, Ruth Poultney, James S. Scott, Per H. Svensson, Joseph Sweeney

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

Original language	English
Pages (from-to)	600-604
Journal	MedChemComm
Volume	3
Issue number	5
DOIs	https://doi.org/10.1039/c2md20054f
Publication status	Published - May 2012

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title = "Oxadiazole isomers: all bioisosteres are not created equal",

abstract = "Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.",

author = "Kristin Goldberg and Sam Groombridge and Julian Hudson and Leach, {Andrew G.} and MacFaul, {Philip A.} and Adrian Pickup and Ruth Poultney and Scott, {James S.} and Svensson, {Per H.} and Joseph Sweeney",

year = "2012",

month = may,

doi = "10.1039/c2md20054f",

language = "English",

volume = "3",

pages = "600--604",

journal = "MedChemComm",

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publisher = "Royal Society of Chemistry",

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T2 - all bioisosteres are not created equal

AU - Goldberg, Kristin

AU - Groombridge, Sam

AU - Hudson, Julian

AU - Leach, Andrew G.

AU - MacFaul, Philip A.

AU - Pickup, Adrian

AU - Poultney, Ruth

AU - Scott, James S.

AU - Svensson, Per H.

AU - Sweeney, Joseph

PY - 2012/5

Y1 - 2012/5

N2 - Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

AB - Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

U2 - 10.1039/c2md20054f

DO - 10.1039/c2md20054f

M3 - Article

SN - 2040-2503

VL - 3

SP - 600

EP - 604

JO - MedChemComm

JF - MedChemComm

IS - 5

ER -

Oxadiazole isomers: all bioisosteres are not created equal

Abstract

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