Oxidant stress in type I autoimmune hepatitis: The link between necroinflammation and fibrogenesis?

Raymond Mcmahon, Philip W. Pemberton, Ali Aboutwerat, Alexander Smith, Peter C. Burrows, Raymond F T McMahon, Thomas W. Warnes

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Autoimmune hepatitis (AIH) is a chronic liver disease of unknown aetiology characterized by circulating autoantibodies, hyperglobulinaemia and interface hepatitis. The mechanisms of progression from initial autoimmune attack to fibrosis and cirrhosis are unclear but oxidant stress may be involved. Markers of lipid peroxidation, antioxidant status, hepatic fibrogenesis and liver function were measured in blood and urine in 35 controls and in 33 patients with type-1 AIH; histology was assessed in 18 patients. In AIH, markers of lipid peroxidation were significantly elevated (8-isoprostane in both plasma and urine P
    Original languageEnglish
    Pages (from-to)182-189
    Number of pages7
    JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
    Volume1689
    Issue number3
    DOIs
    Publication statusPublished - 4 Aug 2004

    Keywords

    • 8-Isoprostane
    • AIH
    • alanine transaminase
    • alkaline phosphatase
    • ALP
    • ALT
    • Antioxidant
    • aspartate transaminase
    • AST
    • autoimmune hepatitis
    • Autoimmune hepatitis
    • Cirrhosis
    • DETBARS
    • Lipid peroxidation
    • Oxidant stress

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