Oxidant stress is a significant feature of primary biliary cirrhosis

Raymond Mcmahon; Ali Aboutwerat; Philip W. Pemberton; Alexander Smith; Peter C. Burrows; Raymond F T McMahon; Sanjiv K. Jain; Thomas W. Warnes

doi:10.1016/S0925-4439(02)00225-9

Oxidant stress is a significant feature of primary biliary cirrhosis

Raymond Mcmahon, Ali Aboutwerat, Philip W. Pemberton, Alexander Smith, Peter C. Burrows, Raymond F T McMahon, Sanjiv K. Jain, Thomas W. Warnes

Research output: Contribution to journal › Article › peer-review

Abstract

Primary biliary cirrhosis (PBC) is a chronic cholestatic disorder characterised by an immunological, and often granulomatous, attack on bile ducts leading to fibrosis, cirrhosis, liver failure and death. Animal and human studies suggest that oxidant stress plays a key role in progression of other liver diseases, but no comprehensive investigation has been performed previously in PBC. A wide range of lipid peroxidation and antioxidant markers were measured in the blood and urine of 41 patients with histologically confirmed PBC. Lipid peroxidation markers were significantly elevated [plasma and urinary 8-isoprostane, P

Original language	English
Pages (from-to)	142-150
Number of pages	8
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1637
Issue number	2
DOIs	https://doi.org/10.1016/S0925-4439(02)00225-9
Publication status	Published - 20 Mar 2003

Keywords

Antioxidant
Lipid peroxidation
Oxidant stress
Primary biliary cirrhosis

Access to Document

10.1016/S0925-4439(02)00225-9

Cite this

@article{28aa9a66eed64ee7b8bf0579a87a8fa0,

title = "Oxidant stress is a significant feature of primary biliary cirrhosis",

abstract = "Primary biliary cirrhosis (PBC) is a chronic cholestatic disorder characterised by an immunological, and often granulomatous, attack on bile ducts leading to fibrosis, cirrhosis, liver failure and death. Animal and human studies suggest that oxidant stress plays a key role in progression of other liver diseases, but no comprehensive investigation has been performed previously in PBC. A wide range of lipid peroxidation and antioxidant markers were measured in the blood and urine of 41 patients with histologically confirmed PBC. Lipid peroxidation markers were significantly elevated [plasma and urinary 8-isoprostane, P",

keywords = "Antioxidant, Lipid peroxidation, Oxidant stress, Primary biliary cirrhosis",

author = "Raymond Mcmahon and Ali Aboutwerat and Pemberton, {Philip W.} and Alexander Smith and Burrows, {Peter C.} and McMahon, {Raymond F T} and Jain, {Sanjiv K.} and Warnes, {Thomas W.}",

year = "2003",

month = mar,

day = "20",

doi = "10.1016/S0925-4439(02)00225-9",

language = "English",

volume = "1637",

pages = "142--150",

journal = "Biochimica et Biophysica Acta - Molecular Basis of Disease",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Oxidant stress is a significant feature of primary biliary cirrhosis

AU - Mcmahon, Raymond

AU - Aboutwerat, Ali

AU - Pemberton, Philip W.

AU - Smith, Alexander

AU - Burrows, Peter C.

AU - McMahon, Raymond F T

AU - Jain, Sanjiv K.

AU - Warnes, Thomas W.

PY - 2003/3/20

Y1 - 2003/3/20

N2 - Primary biliary cirrhosis (PBC) is a chronic cholestatic disorder characterised by an immunological, and often granulomatous, attack on bile ducts leading to fibrosis, cirrhosis, liver failure and death. Animal and human studies suggest that oxidant stress plays a key role in progression of other liver diseases, but no comprehensive investigation has been performed previously in PBC. A wide range of lipid peroxidation and antioxidant markers were measured in the blood and urine of 41 patients with histologically confirmed PBC. Lipid peroxidation markers were significantly elevated [plasma and urinary 8-isoprostane, P

AB - Primary biliary cirrhosis (PBC) is a chronic cholestatic disorder characterised by an immunological, and often granulomatous, attack on bile ducts leading to fibrosis, cirrhosis, liver failure and death. Animal and human studies suggest that oxidant stress plays a key role in progression of other liver diseases, but no comprehensive investigation has been performed previously in PBC. A wide range of lipid peroxidation and antioxidant markers were measured in the blood and urine of 41 patients with histologically confirmed PBC. Lipid peroxidation markers were significantly elevated [plasma and urinary 8-isoprostane, P

KW - Antioxidant

KW - Lipid peroxidation

KW - Oxidant stress

KW - Primary biliary cirrhosis

U2 - 10.1016/S0925-4439(02)00225-9

DO - 10.1016/S0925-4439(02)00225-9

M3 - Article

C2 - 12633902

VL - 1637

SP - 142

EP - 150

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

IS - 2

ER -

Oxidant stress is a significant feature of primary biliary cirrhosis

Abstract

Keywords

Access to Document

Fingerprint

Cite this