Oxidation-sensitive polymeric nanoparticles

Annemie Rehor, Jeffrey A. Hubbell, Nicola Tirelli

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We have recently demonstrated the possible use of organic polysulfides for the design of oxidation-sensitive colloidal carriers in the form of polymeric vesicles, which are particularly suitable for the encapsulation of hydrosoluble drugs. In the present research we extend our efforts to carriers specifically suitable for hydrophobic molecules. Exploiting the living emulsion polymerization of episulfides, we have produced new cross-linked polysulfide nanoparticles. Here we demonstrate how this process allows the production of stable nanoparticles with a good control over their size and functionality. The nanoparticles showed negligible cytotoxicity on a fibroblast model; furthermore, they exhibited sensitivity to oxidative conditions, which first produce swelling and then solubilize the material.
    Original languageEnglish
    Pages (from-to)411-417
    Number of pages6
    JournalLangmuir
    Volume21
    Issue number1
    DOIs
    Publication statusPublished - 4 Jan 2005

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