Oxo-ester mediated native chemical ligation on microarrays: An efficient and chemoselective coupling methodology

Martin J. Weissenborn; Roberto Castangia; Johannes W. Wehner; Robert Šardzík; Thisbe K. Lindhorst; Sabine L. Flitsch

doi:10.1039/c2cc30844d

Oxo-ester mediated native chemical ligation on microarrays: An efficient and chemoselective coupling methodology

Martin J. Weissenborn, Roberto Castangia, Johannes W. Wehner, Robert Šardzík, Thisbe K. Lindhorst, Sabine L. Flitsch

Research output: Contribution to journal › Article › peer-review

Abstract

We report a highly efficient and selective method for the coupling of peptides and glycoconjugates bearing N-terminal cysteines to activated surfaces. This chemoselective method generates stable amide linkages without using any thiol additives. © 2012 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	4444-4446
Number of pages	2
Journal	Chemical Communications
Volume	48
Issue number	37
DOIs	https://doi.org/10.1039/c2cc30844d
Publication status	Published - 11 May 2012

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title = "Oxo-ester mediated native chemical ligation on microarrays: An efficient and chemoselective coupling methodology",

abstract = "We report a highly efficient and selective method for the coupling of peptides and glycoconjugates bearing N-terminal cysteines to activated surfaces. This chemoselective method generates stable amide linkages without using any thiol additives. {\textcopyright} 2012 The Royal Society of Chemistry.",

author = "Weissenborn, {Martin J.} and Roberto Castangia and Wehner, {Johannes W.} and Robert {\v S}ardz{\'i}k and Lindhorst, {Thisbe K.} and Flitsch, {Sabine L.}",

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AU - Weissenborn, Martin J.

AU - Castangia, Roberto

AU - Wehner, Johannes W.

AU - Šardzík, Robert

AU - Lindhorst, Thisbe K.

AU - Flitsch, Sabine L.

PY - 2012/5/11

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N2 - We report a highly efficient and selective method for the coupling of peptides and glycoconjugates bearing N-terminal cysteines to activated surfaces. This chemoselective method generates stable amide linkages without using any thiol additives. © 2012 The Royal Society of Chemistry.

AB - We report a highly efficient and selective method for the coupling of peptides and glycoconjugates bearing N-terminal cysteines to activated surfaces. This chemoselective method generates stable amide linkages without using any thiol additives. © 2012 The Royal Society of Chemistry.

U2 - 10.1039/c2cc30844d

DO - 10.1039/c2cc30844d

M3 - Article

SN - 1359-7345

VL - 48

SP - 4444

EP - 4446

JO - Chemical Communications

JF - Chemical Communications

IS - 37

ER -

Oxo-ester mediated native chemical ligation on microarrays: An efficient and chemoselective coupling methodology

Abstract

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