Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients

Ahmed Salem; Ross Little; Adam Featherstone; Muhammad Babur; Hitesh Mistry; Susan Cheung; Yvonne Watson; Victoria Tessyman; Marie-Claude Asselin; Alan Jackson; Kaye Williams; Geoffrey Parker; Corinne Faivre-Finn; James O'Connor

Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients

Ahmed Salem, Ross Little, Adam Featherstone, Muhammad Babur, Hitesh Mistry, Susan Cheung, Yvonne Watson, Victoria Tessyman, Marie-Claude Asselin, Alan Jackson, Kaye Williams, Geoffrey Parker, Corinne Faivre-Finn, James O'Connor

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Oxygen-enhanced MRI (OE-MRI) has shown promise as a technique for quantifying and spatially mapping tumour hypoxia. Here, we report a world first-in-man study showing that OE-MRI signals in perfused tumour can non-invasively track changes in hypoxia induced by radiotherapy. We show that OE-MRI detects (1) reduction in hypoxia in Calu6 xenografts and that this change is due to hypoxia modification; and (2) reduction in hypoxia is also seen in 14 patients with non-small cell lung cancer. These data support first-in-man use of OE-MRI biomarkers in clinical trials of (chemo)-radiotherapy as single agent or in combination with hypoxia-modifying agents.

Original language	English
Title of host publication	ISMRM 2018
Number of pages	1
Publication status	Published - 1 Jun 2018

Publication series

Name
ISSN (Electronic)	1545-4428

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

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Salem, A., Little, R., Featherstone, A., Babur, M., Mistry, H., Cheung, S., Watson, Y., Tessyman, V., Asselin, M.-C., Jackson, A., Williams, K., Parker, G., Faivre-Finn, C., & O'Connor, J. (2018). Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients. In ISMRM 2018 http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/0123.html

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title = "Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients",

abstract = "Oxygen-enhanced MRI (OE-MRI) has shown promise as a technique for quantifying and spatially mapping tumour hypoxia. Here, we report a world first-in-man study showing that OE-MRI signals in perfused tumour can non-invasively track changes in hypoxia induced by radiotherapy. We show that OE-MRI detects (1) reduction in hypoxia in Calu6 xenografts and that this change is due to hypoxia modification; and (2) reduction in hypoxia is also seen in 14 patients with non-small cell lung cancer. These data support first-in-man use of OE-MRI biomarkers in clinical trials of (chemo)-radiotherapy as single agent or in combination with hypoxia-modifying agents.",

author = "Ahmed Salem and Ross Little and Adam Featherstone and Muhammad Babur and Hitesh Mistry and Susan Cheung and Yvonne Watson and Victoria Tessyman and Marie-Claude Asselin and Alan Jackson and Kaye Williams and Geoffrey Parker and Corinne Faivre-Finn and James O'Connor",

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Salem, A, Little, R, Featherstone, A, Babur, M, Mistry, H, Cheung, S, Watson, Y, Tessyman, V, Asselin, M-C , Jackson, A , Williams, K, Parker, G, Faivre-Finn, C & O'Connor, J 2018, Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients. in ISMRM 2018. <http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/0123.html>

TY - GEN

T1 - Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients

AU - Salem, Ahmed

AU - Little, Ross

AU - Featherstone, Adam

AU - Babur, Muhammad

AU - Mistry, Hitesh

AU - Cheung, Susan

AU - Watson, Yvonne

AU - Tessyman, Victoria

AU - Asselin, Marie-Claude

AU - Jackson, Alan

AU - Williams, Kaye

AU - Parker, Geoffrey

AU - Faivre-Finn, Corinne

AU - O'Connor, James

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Oxygen-enhanced MRI (OE-MRI) has shown promise as a technique for quantifying and spatially mapping tumour hypoxia. Here, we report a world first-in-man study showing that OE-MRI signals in perfused tumour can non-invasively track changes in hypoxia induced by radiotherapy. We show that OE-MRI detects (1) reduction in hypoxia in Calu6 xenografts and that this change is due to hypoxia modification; and (2) reduction in hypoxia is also seen in 14 patients with non-small cell lung cancer. These data support first-in-man use of OE-MRI biomarkers in clinical trials of (chemo)-radiotherapy as single agent or in combination with hypoxia-modifying agents.

AB - Oxygen-enhanced MRI (OE-MRI) has shown promise as a technique for quantifying and spatially mapping tumour hypoxia. Here, we report a world first-in-man study showing that OE-MRI signals in perfused tumour can non-invasively track changes in hypoxia induced by radiotherapy. We show that OE-MRI detects (1) reduction in hypoxia in Calu6 xenografts and that this change is due to hypoxia modification; and (2) reduction in hypoxia is also seen in 14 patients with non-small cell lung cancer. These data support first-in-man use of OE-MRI biomarkers in clinical trials of (chemo)-radiotherapy as single agent or in combination with hypoxia-modifying agents.

M3 - Conference contribution

BT - ISMRM 2018

ER -

Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients

Abstract

Publication series

Research Beacons, Institutes and Platforms

UN SDGs

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