Oxygen Extraction Fraction is higher in elderly participants with a higher cardiovascular disease risk; a combined QSM and ASL study

John McFadden; Julian Matthews; Karl Herholz; Ben Dickie; Hamied Haroon; Oliver Sparasci; Saadat Ahmed; Natalia Kyrtata; Geoffrey Parker; Hedley Emsley; Maélène Lohezic; Laura Parkes

doi:10.58530/2022/1222

Oxygen Extraction Fraction is higher in elderly participants with a higher cardiovascular disease risk; a combined QSM and ASL study

John McFadden, Julian Matthews, Karl Herholz, Ben Dickie, Hamied Haroon, Oliver Sparasci, Saadat Ahmed, Natalia Kyrtata, Geoffrey Parker, Hedley Emsley, Maélène Lohezic, Laura Parkes

Research output: Contribution to conference › Paper › peer-review

Abstract

We investigated quantitative susceptibility mapping (QSM) and arterial spin labelling (ASL) to measure cerebrovascular parameters in elderly people with a range of vascular disease risk (QRisk) and cognitive impairment. Cerebral blood flow (CBF) and arterial transit time (ATT) were derived from ASL and oxygen extraction fraction (OEF) from QSM. Regional estimates were obtained by matching six large veins to their draining territories. QRisk had a significant positive relationship with ATT. OEF had a significant compensatory increase with altered ATT and CBF. Both OEF and ATT were found to be elevated with impaired cognition.

Original language	English
DOIs	https://doi.org/10.58530/2022/1222
Publication status	Published - 2022

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title = "Oxygen Extraction Fraction is higher in elderly participants with a higher cardiovascular disease risk; a combined QSM and ASL study",

abstract = "We investigated quantitative susceptibility mapping (QSM) and arterial spin labelling (ASL) to measure cerebrovascular parameters in elderly people with a range of vascular disease risk (QRisk) and cognitive impairment. Cerebral blood flow (CBF) and arterial transit time (ATT) were derived from ASL and oxygen extraction fraction (OEF) from QSM. Regional estimates were obtained by matching six large veins to their draining territories. QRisk had a significant positive relationship with ATT. OEF had a significant compensatory increase with altered ATT and CBF. Both OEF and ATT were found to be elevated with impaired cognition.",

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TY - CONF

T1 - Oxygen Extraction Fraction is higher in elderly participants with a higher cardiovascular disease risk; a combined QSM and ASL study

AU - McFadden, John

AU - Matthews, Julian

AU - Herholz, Karl

AU - Dickie, Ben

AU - Haroon, Hamied

AU - Sparasci, Oliver

AU - Ahmed, Saadat

AU - Kyrtata, Natalia

AU - Parker, Geoffrey

AU - Emsley, Hedley

AU - Lohezic, Maélène

AU - Parkes, Laura

PY - 2022

Y1 - 2022

N2 - We investigated quantitative susceptibility mapping (QSM) and arterial spin labelling (ASL) to measure cerebrovascular parameters in elderly people with a range of vascular disease risk (QRisk) and cognitive impairment. Cerebral blood flow (CBF) and arterial transit time (ATT) were derived from ASL and oxygen extraction fraction (OEF) from QSM. Regional estimates were obtained by matching six large veins to their draining territories. QRisk had a significant positive relationship with ATT. OEF had a significant compensatory increase with altered ATT and CBF. Both OEF and ATT were found to be elevated with impaired cognition.

AB - We investigated quantitative susceptibility mapping (QSM) and arterial spin labelling (ASL) to measure cerebrovascular parameters in elderly people with a range of vascular disease risk (QRisk) and cognitive impairment. Cerebral blood flow (CBF) and arterial transit time (ATT) were derived from ASL and oxygen extraction fraction (OEF) from QSM. Regional estimates were obtained by matching six large veins to their draining territories. QRisk had a significant positive relationship with ATT. OEF had a significant compensatory increase with altered ATT and CBF. Both OEF and ATT were found to be elevated with impaired cognition.

UR - https://www.mendeley.com/catalogue/12a73ea1-be55-3e58-9096-0ca91daee846/

U2 - 10.58530/2022/1222

DO - 10.58530/2022/1222

M3 - Paper

ER -

Oxygen Extraction Fraction is higher in elderly participants with a higher cardiovascular disease risk; a combined QSM and ASL study

Abstract

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