Oxygen-induced changes in longitudinal relaxation times in skeletal muscle

Deirdre M. McGrath; Josephine H. Naish; James P B O'Connor; Charles E. Hutchinson; John C. Waterton; Chris J. Taylor; Geoffrey J M Parker

doi:10.1016/j.mri.2007.06.011

Oxygen-induced changes in longitudinal relaxation times in skeletal muscle

Deirdre M. McGrath, Josephine H. Naish, James P B O'Connor, Charles E. Hutchinson, John C. Waterton, Chris J. Taylor, Geoffrey J M Parker

Research output: Contribution to journal › Article › peer-review

Abstract

The objective was to measure the effect of 100% oxygen inhalation on T1 relaxation times in skeletal muscle. Healthy volunteers were scanned using three different MRI protocols while breathing medical air and 100% oxygen. Measurements of T1 were made from regions of interest (ROIs) within various skeletal muscle groups. Dynamic data of subjects breathing a sequence of air-oxygen-air allowed the calculation of characteristic wash-in and -out times for dissolved oxygen in muscle. Contrary to previous findings, a statistically significant decrease in T1 in skeletal muscle was observed due to oxygen inhalation. We report approximate baseline characteristic values for the response of skeletal muscle to oxygen inhalation. This measurement may provide new biomarkers for evaluation of oxygen delivery and consumption in normal and diseased skeletal muscle. © 2008 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	221-227
Number of pages	6
Journal	M
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.mri.2007.06.011
Publication status	Published - Feb 2008

Keywords

Biomarker
Oxygen enhancement
Skeletal muscle
T1 relaxation

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10.1016/j.mri.2007.06.011

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title = "Oxygen-induced changes in longitudinal relaxation times in skeletal muscle",

abstract = "The objective was to measure the effect of 100% oxygen inhalation on T1 relaxation times in skeletal muscle. Healthy volunteers were scanned using three different MRI protocols while breathing medical air and 100% oxygen. Measurements of T1 were made from regions of interest (ROIs) within various skeletal muscle groups. Dynamic data of subjects breathing a sequence of air-oxygen-air allowed the calculation of characteristic wash-in and -out times for dissolved oxygen in muscle. Contrary to previous findings, a statistically significant decrease in T1 in skeletal muscle was observed due to oxygen inhalation. We report approximate baseline characteristic values for the response of skeletal muscle to oxygen inhalation. This measurement may provide new biomarkers for evaluation of oxygen delivery and consumption in normal and diseased skeletal muscle. {\textcopyright} 2008 Elsevier Inc. All rights reserved.",

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T1 - Oxygen-induced changes in longitudinal relaxation times in skeletal muscle

AU - McGrath, Deirdre M.

AU - Naish, Josephine H.

AU - O'Connor, James P B

AU - Hutchinson, Charles E.

AU - Waterton, John C.

AU - Taylor, Chris J.

AU - Parker, Geoffrey J M

PY - 2008/2

Y1 - 2008/2

N2 - The objective was to measure the effect of 100% oxygen inhalation on T1 relaxation times in skeletal muscle. Healthy volunteers were scanned using three different MRI protocols while breathing medical air and 100% oxygen. Measurements of T1 were made from regions of interest (ROIs) within various skeletal muscle groups. Dynamic data of subjects breathing a sequence of air-oxygen-air allowed the calculation of characteristic wash-in and -out times for dissolved oxygen in muscle. Contrary to previous findings, a statistically significant decrease in T1 in skeletal muscle was observed due to oxygen inhalation. We report approximate baseline characteristic values for the response of skeletal muscle to oxygen inhalation. This measurement may provide new biomarkers for evaluation of oxygen delivery and consumption in normal and diseased skeletal muscle. © 2008 Elsevier Inc. All rights reserved.

AB - The objective was to measure the effect of 100% oxygen inhalation on T1 relaxation times in skeletal muscle. Healthy volunteers were scanned using three different MRI protocols while breathing medical air and 100% oxygen. Measurements of T1 were made from regions of interest (ROIs) within various skeletal muscle groups. Dynamic data of subjects breathing a sequence of air-oxygen-air allowed the calculation of characteristic wash-in and -out times for dissolved oxygen in muscle. Contrary to previous findings, a statistically significant decrease in T1 in skeletal muscle was observed due to oxygen inhalation. We report approximate baseline characteristic values for the response of skeletal muscle to oxygen inhalation. This measurement may provide new biomarkers for evaluation of oxygen delivery and consumption in normal and diseased skeletal muscle. © 2008 Elsevier Inc. All rights reserved.

KW - Biomarker

KW - Oxygen enhancement

KW - Skeletal muscle

KW - T1 relaxation

U2 - 10.1016/j.mri.2007.06.011

DO - 10.1016/j.mri.2007.06.011

M3 - Article

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SN - 1873-5894

VL - 26

SP - 221

EP - 227

JO - M

JF - M

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ER -

Oxygen-induced changes in longitudinal relaxation times in skeletal muscle

Abstract

Keywords

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