P2 receptor-mediated signaling in mast cell biology

Elena Bulanova, Silvia Bulfone-Paus

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and anti-tumor immune responses. In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution of mast cells to the extracellular ATP release and to the maintenance of extracellular nucleotides pool. Recent publications highlight the importance of purinergic signaling for the pathogenesis of chronic airway inflammation. Therefore, the role of ATP and P2 receptors in allergic inflammation with focus on mast cells was analyzed. Finally, ATP functions as mast cell autocrine/paracrine factor and as messenger in intercellular communication between mast cells, nerves, and glia in the central nervous system. © 2009 Springer Science+Business Media B.V.
    Original languageEnglish
    Pages (from-to)3-17
    Number of pages14
    JournalPurinergic Signalling
    Volume6
    Issue number1
    DOIs
    Publication statusPublished - Mar 2010

    Keywords

    • Apoptosis
    • ATP
    • Degranulation
    • Extracellular nucleotides
    • P2X7 receptor
    • Purinoceptors

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