P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh; Rachel Sarig; Elad Bar Natan; Alina Molchadsky; Shalom Madar; Chamutal Bornstein; Yosef Buganim; Tirosh Shapira; Naomi Goldfinger; Ralf Paus; Varda Rotter

doi:10.1016/j.febslet.2010.04.058

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh, Rachel Sarig, Elad Bar Natan, Alina Molchadsky, Shalom Madar, Chamutal Bornstein, Yosef Buganim, Tirosh Shapira, Naomi Goldfinger, Ralf Paus, Varda Rotter

Research output: Contribution to journal › Article › peer-review

Abstract

The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. © 2010 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	2473-2477
Number of pages	4
Journal	FEBS Letters
Volume	584
Issue number	11
DOIs	https://doi.org/10.1016/j.febslet.2010.04.058
Publication status	Published - Jun 2010

Keywords

Alopecia
Chemotherapy-induced alopecia
Cyclophosphamide
Knockout
XEDAR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2010.04.058

Cite this

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title = "P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss",

abstract = "The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. {\textcopyright} 2010 Federation of European Biochemical Societies.",

keywords = "Alopecia, Chemotherapy-induced alopecia, Cyclophosphamide, Knockout, XEDAR",

author = "Ran Brosh and Rachel Sarig and Natan, {Elad Bar} and Alina Molchadsky and Shalom Madar and Chamutal Bornstein and Yosef Buganim and Tirosh Shapira and Naomi Goldfinger and Ralf Paus and Varda Rotter",

year = "2010",

month = jun,

doi = "10.1016/j.febslet.2010.04.058",

language = "English",

volume = "584",

pages = "2473--2477",

journal = "FEBS Letters",

publisher = "Elsevier BV",

number = "11",

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TY - JOUR

T1 - P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

AU - Brosh, Ran

AU - Sarig, Rachel

AU - Natan, Elad Bar

AU - Molchadsky, Alina

AU - Madar, Shalom

AU - Bornstein, Chamutal

AU - Buganim, Yosef

AU - Shapira, Tirosh

AU - Goldfinger, Naomi

AU - Paus, Ralf

AU - Rotter, Varda

PY - 2010/6

Y1 - 2010/6

N2 - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. © 2010 Federation of European Biochemical Societies.

AB - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. © 2010 Federation of European Biochemical Societies.

KW - Alopecia

KW - Chemotherapy-induced alopecia

KW - Cyclophosphamide

KW - Knockout

KW - XEDAR

U2 - 10.1016/j.febslet.2010.04.058

DO - 10.1016/j.febslet.2010.04.058

M3 - Article

C2 - 20434500

VL - 584

SP - 2473

EP - 2477

JO - FEBS Letters

JF - FEBS Letters

IS - 11

ER -

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Abstract

Keywords

UN SDGs

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