PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population

Marian L. Burr; Haris Naseem; Anne Hinks; Steve Eyre; Laura J. Gibbons; John Bowes; Anthony G. Wilson; James Maxwell; Ann W. Morgan; Paul Emery; Sophia Steer; Lynne Hocking; David M. Reid; Paul Wordsworth; Pille Harrison; Wendy Thomson; Jane Worthington; Anne Barton

doi:10.1136/ard.2009.111294

PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population

Marian L. Burr, Haris Naseem, Anne Hinks, Steve Eyre, Laura J. Gibbons, John Bowes, Anthony G. Wilson, James Maxwell, Ann W. Morgan, Paul Emery, Sophia Steer, Lynne Hocking, David M. Reid, Paul Wordsworth, Pille Harrison, Wendy Thomson, Jane Worthington, Anne Barton

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Polymorphisms of the peptidylarginine deiminase type 4 (PADI4) gene confer susceptibility to rheumatoid arthritis (RA) in East Asian people. However, studies in European populations have produced conflicting results. This study explored the association of the PADI4 genotype with RA in a large UK Caucasian population. Methods: The PADI4-94 (rs2240340) single nucleotide polymorphism (SNP) was directly genotyped in a cohort of unrelated UK Caucasian patients with RA (n=3732) and population controls (n=3039). Imputed data from the Wellcome Trust Case Control Consortium (WTCCC) was used to investigate the association of PADI4-94 with RA in an independent group of RA cases (n=1859) and controls (n=10 599). A further 56 SNPs spanning the PADI4 gene were investigated for association with RA using data from the WTCCC study. Results: The PADI4-94 genotype was not associated with RA in either the present cohort or the WTCCC cohort. Combined analysis of all the cases of RA (n=5591) and controls (n=13 638) gave an overall OR of 1.01 (95% CI 0.96 to 1.05, p=0.72). No association with anti-CCP antibodies and no interaction with either shared epitope or PTPN22 was detected. No evidence for association with RA was identified for any of the PADI4 SNPs investigated. Meta-analysis of previously published studies and our data confirmed no significant association between the PADI4-94 genotype and RA in people of European descent (OR 1.06, 95% CI 0.99 to 1.13, p=0.12). Conclusion: In the largest study performed to date, the PADI4 genotype was not a significant risk factor for RA in people of European ancestry, in contrast to Asian populations.

Original language	English
Pages (from-to)	666-670
Number of pages	4
Journal	Annals of the rheumatic diseases
Volume	69
Issue number	4
DOIs	https://doi.org/10.1136/ard.2009.111294
Publication status	Published - Apr 2010

Access to Document

10.1136/ard.2009.111294

http://ard.bmj.com/content/69/4/666.full.pdf

Cite this

Burr, M. L., Naseem, H., Hinks, A., Eyre, S., Gibbons, L. J., Bowes, J., Wilson, A. G., Maxwell, J., Morgan, A. W., Emery, P., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., Harrison, P., Thomson, W., Worthington, J., & Barton, A. (2010). PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population. Annals of the rheumatic diseases, 69(4), 666-670. https://doi.org/10.1136/ard.2009.111294

@article{5f198ba0babf4b4a8e72675a05e87b7a,

title = "PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population",

abstract = "Background: Polymorphisms of the peptidylarginine deiminase type 4 (PADI4) gene confer susceptibility to rheumatoid arthritis (RA) in East Asian people. However, studies in European populations have produced conflicting results. This study explored the association of the PADI4 genotype with RA in a large UK Caucasian population. Methods: The PADI4-94 (rs2240340) single nucleotide polymorphism (SNP) was directly genotyped in a cohort of unrelated UK Caucasian patients with RA (n=3732) and population controls (n=3039). Imputed data from the Wellcome Trust Case Control Consortium (WTCCC) was used to investigate the association of PADI4-94 with RA in an independent group of RA cases (n=1859) and controls (n=10 599). A further 56 SNPs spanning the PADI4 gene were investigated for association with RA using data from the WTCCC study. Results: The PADI4-94 genotype was not associated with RA in either the present cohort or the WTCCC cohort. Combined analysis of all the cases of RA (n=5591) and controls (n=13 638) gave an overall OR of 1.01 (95% CI 0.96 to 1.05, p=0.72). No association with anti-CCP antibodies and no interaction with either shared epitope or PTPN22 was detected. No evidence for association with RA was identified for any of the PADI4 SNPs investigated. Meta-analysis of previously published studies and our data confirmed no significant association between the PADI4-94 genotype and RA in people of European descent (OR 1.06, 95% CI 0.99 to 1.13, p=0.12). Conclusion: In the largest study performed to date, the PADI4 genotype was not a significant risk factor for RA in people of European ancestry, in contrast to Asian populations.",

author = "Burr, {Marian L.} and Haris Naseem and Anne Hinks and Steve Eyre and Gibbons, {Laura J.} and John Bowes and Wilson, {Anthony G.} and James Maxwell and Morgan, {Ann W.} and Paul Emery and Sophia Steer and Lynne Hocking and Reid, {David M.} and Paul Wordsworth and Pille Harrison and Wendy Thomson and Jane Worthington and Anne Barton",

year = "2010",

month = apr,

doi = "10.1136/ard.2009.111294",

language = "English",

volume = "69",

pages = "666--670",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "Elsevier BV",

number = "4",

}

Burr, ML, Naseem, H, Hinks, A, Eyre, S, Gibbons, LJ, Bowes, J, Wilson, AG, Maxwell, J, Morgan, AW, Emery, P, Steer, S, Hocking, L, Reid, DM, Wordsworth, P, Harrison, P, Thomson, W , Worthington, J & Barton, A 2010, 'PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population', Annals of the rheumatic diseases, vol. 69, no. 4, pp. 666-670. https://doi.org/10.1136/ard.2009.111294

TY - JOUR

T1 - PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population

AU - Burr, Marian L.

AU - Naseem, Haris

AU - Hinks, Anne

AU - Eyre, Steve

AU - Gibbons, Laura J.

AU - Bowes, John

AU - Wilson, Anthony G.

AU - Maxwell, James

AU - Morgan, Ann W.

AU - Emery, Paul

AU - Steer, Sophia

AU - Hocking, Lynne

AU - Reid, David M.

AU - Wordsworth, Paul

AU - Harrison, Pille

AU - Thomson, Wendy

AU - Worthington, Jane

AU - Barton, Anne

PY - 2010/4

Y1 - 2010/4

N2 - Background: Polymorphisms of the peptidylarginine deiminase type 4 (PADI4) gene confer susceptibility to rheumatoid arthritis (RA) in East Asian people. However, studies in European populations have produced conflicting results. This study explored the association of the PADI4 genotype with RA in a large UK Caucasian population. Methods: The PADI4-94 (rs2240340) single nucleotide polymorphism (SNP) was directly genotyped in a cohort of unrelated UK Caucasian patients with RA (n=3732) and population controls (n=3039). Imputed data from the Wellcome Trust Case Control Consortium (WTCCC) was used to investigate the association of PADI4-94 with RA in an independent group of RA cases (n=1859) and controls (n=10 599). A further 56 SNPs spanning the PADI4 gene were investigated for association with RA using data from the WTCCC study. Results: The PADI4-94 genotype was not associated with RA in either the present cohort or the WTCCC cohort. Combined analysis of all the cases of RA (n=5591) and controls (n=13 638) gave an overall OR of 1.01 (95% CI 0.96 to 1.05, p=0.72). No association with anti-CCP antibodies and no interaction with either shared epitope or PTPN22 was detected. No evidence for association with RA was identified for any of the PADI4 SNPs investigated. Meta-analysis of previously published studies and our data confirmed no significant association between the PADI4-94 genotype and RA in people of European descent (OR 1.06, 95% CI 0.99 to 1.13, p=0.12). Conclusion: In the largest study performed to date, the PADI4 genotype was not a significant risk factor for RA in people of European ancestry, in contrast to Asian populations.

AB - Background: Polymorphisms of the peptidylarginine deiminase type 4 (PADI4) gene confer susceptibility to rheumatoid arthritis (RA) in East Asian people. However, studies in European populations have produced conflicting results. This study explored the association of the PADI4 genotype with RA in a large UK Caucasian population. Methods: The PADI4-94 (rs2240340) single nucleotide polymorphism (SNP) was directly genotyped in a cohort of unrelated UK Caucasian patients with RA (n=3732) and population controls (n=3039). Imputed data from the Wellcome Trust Case Control Consortium (WTCCC) was used to investigate the association of PADI4-94 with RA in an independent group of RA cases (n=1859) and controls (n=10 599). A further 56 SNPs spanning the PADI4 gene were investigated for association with RA using data from the WTCCC study. Results: The PADI4-94 genotype was not associated with RA in either the present cohort or the WTCCC cohort. Combined analysis of all the cases of RA (n=5591) and controls (n=13 638) gave an overall OR of 1.01 (95% CI 0.96 to 1.05, p=0.72). No association with anti-CCP antibodies and no interaction with either shared epitope or PTPN22 was detected. No evidence for association with RA was identified for any of the PADI4 SNPs investigated. Meta-analysis of previously published studies and our data confirmed no significant association between the PADI4-94 genotype and RA in people of European descent (OR 1.06, 95% CI 0.99 to 1.13, p=0.12). Conclusion: In the largest study performed to date, the PADI4 genotype was not a significant risk factor for RA in people of European ancestry, in contrast to Asian populations.

U2 - 10.1136/ard.2009.111294

DO - 10.1136/ard.2009.111294

M3 - Article

SN - 0003-4967

VL - 69

SP - 666

EP - 670

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 4

ER -

PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population

Abstract

Access to Document

Fingerprint

Cite this