Pannexin 1 forms an anion-selective channel

Weihong Ma, Vincent Compan, Wenxuan Zheng, Elizabeth Martin, R. Alan North, Alexei Verkhratsky, Annmarie Surprenant

Research output: Contribution to journalArticlepeer-review

Abstract

Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO 3 ->I ->Br ->Cl ->F -≫aspartate - ≈glutamate -≈gluconate -. Single-channel Panx1-mediated currents have a unitary conductance around 68 pS. Our results show that Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance. © Springer-Verlag 2012.
Original languageEnglish
Pages (from-to)585-592
Number of pages7
JournalPflügers Archiv European Journal of Physiology
Volume463
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Anion channel
  • HEK293
  • Pannexin 1
  • Single channel

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