Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor

Pablo Pelegrin, Annmarie Surprenant

    Research output: Contribution to journalArticlepeer-review

    Abstract

    P2X7 receptors are ATP-gated cation channels; their activation in macrophage also leads to rapid opening of a membrane pore permeable to dyes such as ethidium, and to release of the pro-inflammatory cytokine, interleukin-1β (IL-1β). It has not been known what this dye-uptake path is, or whether it is involved in downstream signalling to IL-1β release. Here, we identify pannexin-1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, as this dye-uptake pathway and show that signalling through pannexin-1 is required for processing of caspase-1 and release of mature IL-1β induced by P2X7 receptor activation. © 2006 European Molecular Biology Organization. All Rights Reserved.
    Original languageEnglish
    Pages (from-to)5071-5082
    Number of pages11
    JournalEMBO Journal
    Volume25
    Issue number21
    DOIs
    Publication statusPublished - 1 Nov 2006

    Keywords

    • Hemichannel
    • Inflammasome
    • Ion channel
    • Pro-inflammatory cytokines
    • Purine receptors

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