Paradoxical elevations in serum IGF-II and IGF binding protein-2 in acromegaly: Insights into the regulation of these peptides

Andrew Renehan; Andrew G. Renehan; Andrew A. Toogood; W. David Ryder; Jenny Jones; Christopher S. Potten; Sarah T. O'Dwyer; Stephen M. Shalet

doi:10.1046/j.1365-2265.2001.01380.x

Paradoxical elevations in serum IGF-II and IGF binding protein-2 in acromegaly: Insights into the regulation of these peptides

Andrew Renehan, Andrew G. Renehan, Andrew A. Toogood, W. David Ryder, Jenny Jones, Christopher S. Potten, Sarah T. O'Dwyer, Stephen M. Shalet

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Circulating insulin-like growth factor (IGF)-II and IGF binding protein-2 (IGFBP-2) are frequently altered, often in parallel, in numerous pathologies including neoplastic disease but little is known about their normal regulation. This study compared serum IGF-II and IGFBP-2 distributions between acromegalics and a large normal adult population to explore possible determinants. PATIENTS: Sixty acromegalic patients undergoing screening colonoscopy (age range 25-81 years); normative data from 306 healthy adults (age range 20-89 years). MEASUREMENTS: Serum IGF-I, IGF-II, IGFBP-2 and IGFBP-3 were measured in healthy adults and acromegalics. Mean growth hormone (GH) levels were obtained for acromegalic patients. Differences were compared using t-tests (unadjusted) and multiple regression models (adjusted for age and gender). Correlations were expressed as Pearson's coefficient (r). RESULTS: For acromegalic patients, GH was significantly correlated with IGF-I (r=0.50; P

Original language	English
Pages (from-to)	469-475
Number of pages	6
Journal	Clinical Endocrinology
Volume	55
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2265.2001.01380.x
Publication status	Published - 2001

Keywords

blood: Acromegaly
Adult
Aged
Aged, 80 and over
Aging
Case-Control Studies
blood: Colorectal Neoplasms
Humans
blood: Insulin-Like Growth Factor Binding Protein 2
blood: Insulin-Like Growth Factor Binding Protein 3
analysis: Insulin-Like Growth Factor I
analysis: Insulin-Like Growth Factor II
Middle Aged
Regression Analysis

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10.1046/j.1365-2265.2001.01380.x

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@article{c83915770d744736852df57f9c0e3ccc,

title = "Paradoxical elevations in serum IGF-II and IGF binding protein-2 in acromegaly: Insights into the regulation of these peptides",

abstract = "OBJECTIVE: Circulating insulin-like growth factor (IGF)-II and IGF binding protein-2 (IGFBP-2) are frequently altered, often in parallel, in numerous pathologies including neoplastic disease but little is known about their normal regulation. This study compared serum IGF-II and IGFBP-2 distributions between acromegalics and a large normal adult population to explore possible determinants. PATIENTS: Sixty acromegalic patients undergoing screening colonoscopy (age range 25-81 years); normative data from 306 healthy adults (age range 20-89 years). MEASUREMENTS: Serum IGF-I, IGF-II, IGFBP-2 and IGFBP-3 were measured in healthy adults and acromegalics. Mean growth hormone (GH) levels were obtained for acromegalic patients. Differences were compared using t-tests (unadjusted) and multiple regression models (adjusted for age and gender). Correlations were expressed as Pearson's coefficient (r). RESULTS: For acromegalic patients, GH was significantly correlated with IGF-I (r=0.50; P",

keywords = "blood: Acromegaly, Adult, Aged, Aged, 80 and over, Aging, Case-Control Studies, blood: Colorectal Neoplasms, Humans, blood: Insulin-Like Growth Factor Binding Protein 2, blood: Insulin-Like Growth Factor Binding Protein 3, analysis: Insulin-Like Growth Factor I, analysis: Insulin-Like Growth Factor II, Middle Aged, Regression Analysis",

author = "Andrew Renehan and Renehan, {Andrew G.} and Toogood, {Andrew A.} and {David Ryder}, W. and Jenny Jones and Potten, {Christopher S.} and O'Dwyer, {Sarah T.} and Shalet, {Stephen M.}",

year = "2001",

doi = "10.1046/j.1365-2265.2001.01380.x",

language = "English",

volume = "55",

pages = "469--475",

journal = "Clinical Endocrinology",

issn = "1365-2265",

publisher = "John Wiley & Sons Ltd",

number = "4",

}

TY - JOUR

T1 - Paradoxical elevations in serum IGF-II and IGF binding protein-2 in acromegaly: Insights into the regulation of these peptides

AU - Renehan, Andrew

AU - Renehan, Andrew G.

AU - Toogood, Andrew A.

AU - David Ryder, W.

AU - Jones, Jenny

AU - Potten, Christopher S.

AU - O'Dwyer, Sarah T.

AU - Shalet, Stephen M.

PY - 2001

Y1 - 2001

N2 - OBJECTIVE: Circulating insulin-like growth factor (IGF)-II and IGF binding protein-2 (IGFBP-2) are frequently altered, often in parallel, in numerous pathologies including neoplastic disease but little is known about their normal regulation. This study compared serum IGF-II and IGFBP-2 distributions between acromegalics and a large normal adult population to explore possible determinants. PATIENTS: Sixty acromegalic patients undergoing screening colonoscopy (age range 25-81 years); normative data from 306 healthy adults (age range 20-89 years). MEASUREMENTS: Serum IGF-I, IGF-II, IGFBP-2 and IGFBP-3 were measured in healthy adults and acromegalics. Mean growth hormone (GH) levels were obtained for acromegalic patients. Differences were compared using t-tests (unadjusted) and multiple regression models (adjusted for age and gender). Correlations were expressed as Pearson's coefficient (r). RESULTS: For acromegalic patients, GH was significantly correlated with IGF-I (r=0.50; P

AB - OBJECTIVE: Circulating insulin-like growth factor (IGF)-II and IGF binding protein-2 (IGFBP-2) are frequently altered, often in parallel, in numerous pathologies including neoplastic disease but little is known about their normal regulation. This study compared serum IGF-II and IGFBP-2 distributions between acromegalics and a large normal adult population to explore possible determinants. PATIENTS: Sixty acromegalic patients undergoing screening colonoscopy (age range 25-81 years); normative data from 306 healthy adults (age range 20-89 years). MEASUREMENTS: Serum IGF-I, IGF-II, IGFBP-2 and IGFBP-3 were measured in healthy adults and acromegalics. Mean growth hormone (GH) levels were obtained for acromegalic patients. Differences were compared using t-tests (unadjusted) and multiple regression models (adjusted for age and gender). Correlations were expressed as Pearson's coefficient (r). RESULTS: For acromegalic patients, GH was significantly correlated with IGF-I (r=0.50; P

KW - blood: Acromegaly

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging

KW - Case-Control Studies

KW - blood: Colorectal Neoplasms

KW - Humans

KW - blood: Insulin-Like Growth Factor Binding Protein 2

KW - blood: Insulin-Like Growth Factor Binding Protein 3

KW - analysis: Insulin-Like Growth Factor I

KW - analysis: Insulin-Like Growth Factor II

KW - Middle Aged

KW - Regression Analysis

U2 - 10.1046/j.1365-2265.2001.01380.x

DO - 10.1046/j.1365-2265.2001.01380.x

M3 - Article

SN - 1365-2265

VL - 55

SP - 469

EP - 475

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 4

ER -

Paradoxical elevations in serum IGF-II and IGF binding protein-2 in acromegaly: Insights into the regulation of these peptides

Abstract

Keywords

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