Paradoxical expression of E-cadherin in prostatic bone metastases

A. A G Bryden, A. J. Freemont, N. W. Clarke, N. J R George

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective. To determine whether the calcium-dependent cell adhesion molecule E-cadherin is expressed in metastatic deposits of prostate cancer in bone. Patients and methods. Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were obtained and immunohistochemically stained for E-cadherin with the monoclonal antibody HECD-1, using the streptavidin-biotin complex technique. Benign prostatic tissue was used as the control. Results. Of the 10 specimens, nine showed positive expression of E-cadherin, graded as strong in four. E-cadherin expression was strongest in well-differentiated metastases and decreased with increasing tumour grade. In some specimens there were mixed patterns of expression. Conclusion. E-cadherin is strongly expressed in prostatic bone metastases and the degree of expression appears to reflect local tumour grade. This suggests that loss of E-cadherin expression may not be critically linked to metastatic potential.
    Original languageEnglish
    Pages (from-to)1032-1034
    Number of pages2
    JournalBJU international
    Volume84
    Issue number9
    DOIs
    Publication statusPublished - 1999

    Keywords

    • Bone metastases
    • E-cadherin
    • Prostate cancer

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