Parasite-Derived MicroRNAs in Host Serum As Novel Biomarkers of Helminth Infection

Anna M. Hoy; Rachel J. Lundie; Alasdair Ivens; Juan F. Quintana; Norman Nausch; Thorsten Forster; Frances Jones; Narcis B. Kabatereine; David W. Dunne; Francisca Mutapi; Andrew S. MacDonald; Amy H. Buck

doi:10.1371/journal.pntd.0002701

Parasite-Derived MicroRNAs in Host Serum As Novel Biomarkers of Helminth Infection

Anna M. Hoy, Rachel J. Lundie, Alasdair Ivens, Juan F. Quintana, Norman Nausch, Thorsten Forster, Frances Jones, Narcis B. Kabatereine, David W. Dunne, Francisca Mutapi, Andrew S. MacDonald, Amy H. Buck

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background:MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host and parasite miRNAs to serve as tissue or serum biomarkers of Schistosoma mansoni infection.Methods/Principal Findings:We used Exiqon miRNA microarrays to profile miRNA expression in the livers of mice infected with S. mansoni at 7 weeks post-infection. Thirty-three mouse miRNAs were differentially expressed in infected compared to naïve mice (>2 fold change, p

Original language	English
Article number	e2701
Journal	PL o S Neglected Tropical Diseases
Volume	8
Issue number	2
DOIs	https://doi.org/10.1371/journal.pntd.0002701
Publication status	Published - 2014

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title = "Parasite-Derived MicroRNAs in Host Serum As Novel Biomarkers of Helminth Infection",

abstract = "Background:MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host and parasite miRNAs to serve as tissue or serum biomarkers of Schistosoma mansoni infection.Methods/Principal Findings:We used Exiqon miRNA microarrays to profile miRNA expression in the livers of mice infected with S. mansoni at 7 weeks post-infection. Thirty-three mouse miRNAs were differentially expressed in infected compared to na{\"i}ve mice (>2 fold change, p",

author = "Hoy, {Anna M.} and Lundie, {Rachel J.} and Alasdair Ivens and Quintana, {Juan F.} and Norman Nausch and Thorsten Forster and Frances Jones and Kabatereine, {Narcis B.} and Dunne, {David W.} and Francisca Mutapi and MacDonald, {Andrew S.} and Buck, {Amy H.}",

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T1 - Parasite-Derived MicroRNAs in Host Serum As Novel Biomarkers of Helminth Infection

AU - Hoy, Anna M.

AU - Lundie, Rachel J.

AU - Ivens, Alasdair

AU - Quintana, Juan F.

AU - Nausch, Norman

AU - Forster, Thorsten

AU - Jones, Frances

AU - Kabatereine, Narcis B.

AU - Dunne, David W.

AU - Mutapi, Francisca

AU - MacDonald, Andrew S.

AU - Buck, Amy H.

N1 - 097394/Z/11/Z, Wellcome Trust, United Kingdom

PY - 2014

Y1 - 2014

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AB - Background:MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host and parasite miRNAs to serve as tissue or serum biomarkers of Schistosoma mansoni infection.Methods/Principal Findings:We used Exiqon miRNA microarrays to profile miRNA expression in the livers of mice infected with S. mansoni at 7 weeks post-infection. Thirty-three mouse miRNAs were differentially expressed in infected compared to naïve mice (>2 fold change, p

U2 - 10.1371/journal.pntd.0002701

DO - 10.1371/journal.pntd.0002701

M3 - Article

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JO - PL o S Neglected Tropical Diseases

JF - PL o S Neglected Tropical Diseases

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ER -

Parasite-Derived MicroRNAs in Host Serum As Novel Biomarkers of Helminth Infection

Abstract

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