Parental Depression Following the Early Diagnosis of Cystic Fibrosis: A Matched, Prospective Study

Claire Glasscoe, Gillian A. Lancaster, Rosalind L. Smyth, Jonathan Hill

    Research output: Contribution to journalArticlepeer-review


    Objective: To assess risks for parental depression following the diagnosis of cystic fibrosis (CF) in a child. Study design: Matched cohort study in NW England; 45 parental couples with a child diagnosed with CF were compared with 45 control couples matching for age, sex, and position in the family of the index child. The Beck Depression Inventory (BDI-II) with a clinical cut-off ≥13 for dysphoria (mild depression) was the main outcome. A stratified analysis was conducted using the Mantel-Haenszel risk-ratio estimator (RRMH) with eight strata for each of the matching variable combinations. Results: Heterogeneity was found within the dataset. Parents with a child with CF ≤9 months of age at baseline had an elevated prospective risk of depression (mothers RRMH [95% confidence interval(CI)] = 2·6[1·05,6·42], fathers RRMH [95%CI] = 2·26 [0·97,5·28]). The absence of a group effect for depression at follow-up after adjusting for the matching (mothers RRMH [95%CI] = 1·1 [0·59,2·05], fathers RRMH [95%CI] = 1·42 [0·66,3·08]) masked this heterogeneity. Conclusion: This hypothesis-generating finding suggests that parents may be more vulnerable to depression when their child is diagnosed with a life-shortening condition during the first few months of life. Mood in parents of infants diagnosed early needs to be monitored longitudinally and preventative strategies devised. © 2007 Mosby, Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)185-191
    Number of pages6
    JournalJournal Of Pediatrics
    Issue number2
    Publication statusPublished - Feb 2007


    • Adult
    • Age Distribution
    • Case-Control Studies
    • Child, Preschool
    • Confidence Intervals
    • diagnosis: Cystic Fibrosis
    • diagnosis: Depression
    • epidemiology: England
    • Female
    • Follow-Up Studies
    • Humans
    • Incidence
    • Infant
    • Male
    • Parent-Child Relations
    • Parenting
    • Prospective Studies
    • Reference Values
    • Severity of Illness Index
    • Sex Distribution


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