Allan Jordan (Inventor), Bohdan Waszkowycz, (Inventor), Colin Hutton (Inventor), Ian Waddell (Inventor), James Hitchin (Inventor), Kate Smith (Inventor), Niall Hamilton (Inventor), Alison Mcgonagle (Inventor)

Research output: Patent


The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

Original languageEnglish
Patent numberWO2016097749
IPCC07D 417/ 14 A I
Priority date19/12/14
Publication statusPublished - 23 Jun 2016

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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