PARG INHIBITORY COMPOUNDS

Allan Jordan; Bohdan Waszkowycz,; Colin Hutton; Ian Waddell; James Hitchin; Kate Smith; Niall Hamilton; Alison Mcgonagle

PARG INHIBITORY COMPOUNDS

Allan Jordan (Inventor), Bohdan Waszkowycz, (Inventor), Colin Hutton (Inventor), Ian Waddell (Inventor), James Hitchin (Inventor), Kate Smith (Inventor), Niall Hamilton (Inventor), Alison Mcgonagle (Inventor)

Cancer Research Technology Limited (t/a Cancer Research Horizons)

Research output: Patent

Abstract

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

Original language	English
Patent number	WO2016097749
IPC	C07D 417/ 14 A I
Priority date	19/12/14
Publication status	Published - 23 Jun 2016

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "PARG INHIBITORY COMPOUNDS",

abstract = "The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.",

author = "Allan Jordan and Bohdan Waszkowycz, and Colin Hutton and Ian Waddell and James Hitchin and Kate Smith and Niall Hamilton and Alison Mcgonagle",

year = "2016",

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day = "23",

language = "English",

type = "Patent",

note = "WO2016097749; C07D 417/ 14 A I",

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TY - PAT

T1 - PARG INHIBITORY COMPOUNDS

AU - Jordan, Allan

AU - Waszkowycz,, Bohdan

AU - Hutton, Colin

AU - Waddell, Ian

AU - Hitchin, James

AU - Smith, Kate

AU - Hamilton, Niall

AU - Mcgonagle, Alison

PY - 2016/6/23

Y1 - 2016/6/23

N2 - The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

AB - The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

M3 - Patent

M1 - WO2016097749

ER -

PARG INHIBITORY COMPOUNDS

Abstract

Research Beacons, Institutes and Platforms

UN SDGs

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