Participation in community-based lung cancer screening: the Yorkshire Lung Screening Trial

Philip Crosbie, Rhian Gabe, Irene Simmonds, Neil Hancock, Panos Alexandris, Martyn Kennedy, Suzanne Rogerson, David Baldwin, Richard Booton, Claire Bradley, Mike Darby, Claire Eckert, Kevin N Franks, Jason Lindop, Sam M. Janes, Henrik Møller, Rachel L. Murray, Richard D. Neal, Samantha L. Quaife, Sara UppertonBethany Shinkins, Puvan Tharmanathan, Matthew E. J. Callister

Research output: Contribution to journalArticlepeer-review


Question: Screening with low dose computed tomography (LDCT) reduces lung-cancer mortality; however, the most effective strategy for optimising participation is unknown. Here we present data from the Yorkshire Lung Screening Trial, including response to invitation, screening eligibility and uptake of community-based LDCT screening.
Methods: Individuals aged 55 to 80, identified from primary care records as having ever smoked, were randomised prior to consent to invitation to telephone lung cancer risk assessment or usual care. The invitation strategy included General Practitioner endorsement, pre-invitation and two reminder invitations. After telephone triage, those at higher risk were invited to a Lung Health Check (LHC) with immediate access to a mobile CT scanner.
Results: Of 44,943 individuals invited, 50.8% (n=22,815) responded and underwent telephone-based risk assessment (16.7% and 7.3% following first and second reminders respectively). A lower response rate was associated with current smoking status (adjOR 0.44, 95%CI 0.42-0.46) and socio-economic deprivation (adjOR 0.58, 95% CI 0.54-0.62 most vs. least deprived quintile). Of those responding, 34.4% (n=7,853) were potentially eligible for screening and offered a LHC, of whom 86.8% (n=6,819) attended. Lower uptake was associated with current smoking status (adjOR 0.73, 95%CI 0.62-0.87) and socio-economic deprivation (adjOR 0.78, 95% CI 0.62-0.98). In total 6,650 individuals had a baseline LDCT scan, representing 99.7% of eligible LHC attendees.
Conclusion: Telephone risk assessment followed by a community-based LHC is an effective strategy for lung cancer screening implementation. However, lower participation associated with current smoking status and socio-economic deprivation underlines the importance of research to ensure equitable access to screening.  
Original languageEnglish
JournalEuropean Respiratory Journal
Publication statusPublished - 2022


Dive into the research topics of 'Participation in community-based lung cancer screening: the Yorkshire Lung Screening Trial'. Together they form a unique fingerprint.

Cite this