Particle circulation and oxygen mass transfer in an immobilized cell bioreactor

Jonathan F. Dean, Colin Webb

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Two important considerations in the design of an aerobic particulate immobilized cell bioreactor are the provision of sufficient oxygen to maintain the desired metabolism of the immobilized organism, and the biomass holdup (which is proportional to the number of immobilized cell particles in the reactor). The Circulating Bed Reactor, a reactor developed for use with those forms of immobilization that result in particles of essentially neutral buoyancy, operates with an expanded bed of circulating particles. The particle number density attainable in such a reactor has been found to be dependent upon the circulation cell aspect ratio, the individual particle properties, the static bed voidage of the particles, and the superficial gas velocity. The oxygen mass transfer characteristics have been found to be dependent upon the circulatory nature of the system, the particle (solids) holdup, the particle porosity, and the superficial gas velocity. © 1987 Humana Press Inc.
    Original languageEnglish
    Pages (from-to)227-244
    Number of pages17
    JournalApplied Biochemistry and Biotechnology
    Volume15
    Issue number3
    DOIs
    Publication statusPublished - Oct 1987

    Keywords

    • oxygen mass transfer, in an immobilized cell bioreactor
    • Particle circulation, in an immobilized cell bioreactor

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