Particulate systems for targeting of macrophages: Basic and therapeutic concepts

S. M. Moghimi; L. Parhamifar; D. Ahmadvand; P. P. Wibroe; T. L. Andresen; Z. S. Farhangrazi; A. C. Hunter

doi:10.1159/000339153

Particulate systems for targeting of macrophages: Basic and therapeutic concepts

S. M. Moghimi, L. Parhamifar, D. Ahmadvand, P. P. Wibroe, T. L. Andresen, Z. S. Farhangrazi, A. C. Hunter

Research output: Contribution to journal › Article › peer-review

Abstract

Particulate systems in the form of liposomes, polymeric micelles, polymeric nano-and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug release processes can be optimized through modifications of the drug carrier physicochemical properties, which include hydrodynamic size, shape, composition and surface characteristics. Through such modifications together with understanding of macrophage cell biology, targeting may be aimed at a particular subset of macrophages. Advances in basic and therapeutic concepts of particulate targeting of macrophages and related nanotechnology approaches for immune cell modifications are discussed. © 2012 S. Karger AG, Basel.

Original language	English
Pages (from-to)	509-528
Number of pages	19
Journal	Journal of Innate Immunity
Volume	4
Issue number	5-6
DOIs	https://doi.org/10.1159/000339153
Publication status	Published - Aug 2012

Keywords

Drug delivery
Macrophage diseases
Nanomedicine
Nanoparticles
Phagocytosis

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10.1159/000339153

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abstract = "Particulate systems in the form of liposomes, polymeric micelles, polymeric nano-and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug release processes can be optimized through modifications of the drug carrier physicochemical properties, which include hydrodynamic size, shape, composition and surface characteristics. Through such modifications together with understanding of macrophage cell biology, targeting may be aimed at a particular subset of macrophages. Advances in basic and therapeutic concepts of particulate targeting of macrophages and related nanotechnology approaches for immune cell modifications are discussed. {\textcopyright} 2012 S. Karger AG, Basel.",

keywords = "Drug delivery, Macrophage diseases, Nanomedicine, Nanoparticles, Phagocytosis",

author = "Moghimi, {S. M.} and L. Parhamifar and D. Ahmadvand and Wibroe, {P. P.} and Andresen, {T. L.} and Farhangrazi, {Z. S.} and Hunter, {A. C.}",

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T1 - Particulate systems for targeting of macrophages: Basic and therapeutic concepts

AU - Moghimi, S. M.

AU - Parhamifar, L.

AU - Ahmadvand, D.

AU - Wibroe, P. P.

AU - Andresen, T. L.

AU - Farhangrazi, Z. S.

AU - Hunter, A. C.

PY - 2012/8

Y1 - 2012/8

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AB - Particulate systems in the form of liposomes, polymeric micelles, polymeric nano-and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug release processes can be optimized through modifications of the drug carrier physicochemical properties, which include hydrodynamic size, shape, composition and surface characteristics. Through such modifications together with understanding of macrophage cell biology, targeting may be aimed at a particular subset of macrophages. Advances in basic and therapeutic concepts of particulate targeting of macrophages and related nanotechnology approaches for immune cell modifications are discussed. © 2012 S. Karger AG, Basel.

KW - Drug delivery

KW - Macrophage diseases

KW - Nanomedicine

KW - Nanoparticles

KW - Phagocytosis

U2 - 10.1159/000339153

DO - 10.1159/000339153

M3 - Article

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VL - 4

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EP - 528

JO - Journal of Innate Immunity

JF - Journal of Innate Immunity

IS - 5-6

ER -

Particulate systems for targeting of macrophages: Basic and therapeutic concepts

Abstract

Keywords

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