Pas de deux in groups of four - The biogenesis of KATP channels

Ioana Neagoe; Blanche Schwappach

doi:10.1016/j.yjmcc.2004.11.023

Pas de deux in groups of four - The biogenesis of KATP channels

Ioana Neagoe, Blanche Schwappach

Research output: Contribution to journal › Article › peer-review

Abstract

The biogenesis of KATP channels provides an interesting example of the assembly of structurally very different membrane protein subunits into a heterooligomeric complex. This review summarizes our current knowledge with respect to the protein domains driving heteromultimeric assembly in the endoplasmic reticulum, quality control, as well as the determinants and kinetics of subcellular sorting of the KATP channel complex. The impact of disease-associated mutations on KATP channel biogenesis is discussed. © 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	887-894
Number of pages	7
Journal	Journal of molecular and cellular cardiology
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.yjmcc.2004.11.023
Publication status	Published - Jun 2005

Keywords

Biogenesis
KATP channels
Quality control

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10.1016/j.yjmcc.2004.11.023

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abstract = "The biogenesis of KATP channels provides an interesting example of the assembly of structurally very different membrane protein subunits into a heterooligomeric complex. This review summarizes our current knowledge with respect to the protein domains driving heteromultimeric assembly in the endoplasmic reticulum, quality control, as well as the determinants and kinetics of subcellular sorting of the KATP channel complex. The impact of disease-associated mutations on KATP channel biogenesis is discussed. {\textcopyright} 2005 Elsevier Ltd. All rights reserved.",

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author = "Ioana Neagoe and Blanche Schwappach",

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AU - Neagoe, Ioana

AU - Schwappach, Blanche

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AB - The biogenesis of KATP channels provides an interesting example of the assembly of structurally very different membrane protein subunits into a heterooligomeric complex. This review summarizes our current knowledge with respect to the protein domains driving heteromultimeric assembly in the endoplasmic reticulum, quality control, as well as the determinants and kinetics of subcellular sorting of the KATP channel complex. The impact of disease-associated mutations on KATP channel biogenesis is discussed. © 2005 Elsevier Ltd. All rights reserved.

KW - Biogenesis

KW - KATP channels

KW - Quality control

U2 - 10.1016/j.yjmcc.2004.11.023

DO - 10.1016/j.yjmcc.2004.11.023

M3 - Article

C2 - 15910873

SN - 0022-2828

VL - 38

SP - 887

EP - 894

JO - Journal of molecular and cellular cardiology

JF - Journal of molecular and cellular cardiology

IS - 6

ER -

Pas de deux in groups of four - The biogenesis of KATP channels

Abstract

Keywords

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