Pathogenesis and clinical features of psoriasis

Christopher EM Griffiths, Jonathan NWN Barker

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Psoriasis, a papulosquamous skin disease, was originally thought of as a disorder primarily of epidermal keratinocytes, but is now recognised as one of the commonest immune-mediated disorders. Tumour necrosis factor α, dendritic cells, and T-cells all contribute substantially to its pathogenesis. In early-onset psoriasis (beginning before age 40 years), carriage of HLA-Cw6 and environmental triggers, such as β-haemolytic streptococcal infections, are major determinants of disease expression. Moreover, at least nine chromosomal psoriasis susceptibility loci have been identified. Several clinical phenotypes of psoriasis are recognised, with chronic plaque (psoriasis vulgaris) accounting for 90% of cases. Comorbidities of psoriasis are attracting interest, and include impairment of quality of life and associated depressive illness, cardiovascular disease, and a seronegative arthritis known as psoriatic arthritis. A more complete understanding of underlying pathomechanisms is leading to new treatments, which will be discussed in the second part of this Series. © 2007 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)263-271
    Number of pages8
    JournalThe Lancet
    Volume370
    Issue number9583
    DOIs
    Publication statusPublished - 21 Jul 2007

    Keywords

    • Animals
    • Comorbidity
    • Disease Models, Animal
    • Female
    • Humans
    • Male
    • etiology: Psoriasis
    • Social Isolation

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