Pathophysiological aspects of Aspergillus colonization in disease

Research output: Contribution to journalReview articlepeer-review

Abstract

Aspergillus colonization of the lower respiratory airways is common in normal people, and of little clinical significance. However, in some patients, colonization is associated with severe disease including poorly controlled asthma, allergic bronchopulmonary aspergillosis (ABPA) with sputum plugs, worse lung function in chronic obstructive pulmonary aspergillosis (COPD), invasive aspergillosis, and active infection in patients with chronic pulmonary aspergillosis (CPA). Therefore, understanding the pathophysiological mechanisms of fungal colonization in disease is essential to develop strategies to avert or minimise disease. Aspergillus cell components promoting fungal adherence to the host surface, extracellular matrix, or basal lamina are indispensable for pathogen persistence. However, our understanding of individual differences in clearance of A. Fumigatus from the lung in susceptible patients is close to zero.

Original languageEnglish
Pages (from-to)S219-S227
JournalMedical Mycology
Volume57
Early online date15 Sept 2018
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • aspergillosis
  • Aspergillus
  • colonization

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