Patient factors associated with receipt of combination antipsychotic drug therapy in the treatment of schizophrenia

K. P. Hayhurst; R. J. Drake; S. W. Lewis

doi:10.1177/0269881108095169

Patient factors associated with receipt of combination antipsychotic drug therapy in the treatment of schizophrenia

K. P. Hayhurst, R. J. Drake, S. W. Lewis

Research output: Contribution to journal › Article › peer-review

Abstract

Although discouraged in available treatment guidelines, combination antipsychotic prescribing (CAP) is a common practice in the treatment of schizophrenia. Patient characteristics may be associated with this type of treatment. A dataset (N = 363) derived from parallel randomised controlled trials was interrogated to identify factors associated with the receipt of CAP, and a logistic regression analysis was used to predict the occurrence of CAP. Significant predictors of CAP were longer illness, low global functioning score and high treatment adherence rating. Co-prescribed patients received a higher combined dose. © 2010 British Association for Psychopharmacology.

Original language	English
Pages (from-to)	83-89
Number of pages	6
Journal	Journal of Psychopharmacology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1177/0269881108095169
Publication status	Published - Jan 2010

Keywords

Antipsychotics
Augmentation
Combination treatment
Polypharmacy
Prescribing
Psychosis
Schizophrenia

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10.1177/0269881108095169

1 Doctoral Thesis

Non-evidence-based antipsychotic drug prescribing in the treatment of adult schizophrenia [PhD Thesis].
Hayhurst, K., 2009, University of Manchester. 279 p.
Research output: Thesis › Doctoral Thesis

Cite this

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title = "Patient factors associated with receipt of combination antipsychotic drug therapy in the treatment of schizophrenia",

abstract = "Although discouraged in available treatment guidelines, combination antipsychotic prescribing (CAP) is a common practice in the treatment of schizophrenia. Patient characteristics may be associated with this type of treatment. A dataset (N = 363) derived from parallel randomised controlled trials was interrogated to identify factors associated with the receipt of CAP, and a logistic regression analysis was used to predict the occurrence of CAP. Significant predictors of CAP were longer illness, low global functioning score and high treatment adherence rating. Co-prescribed patients received a higher combined dose. {\textcopyright} 2010 British Association for Psychopharmacology.",

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AB - Although discouraged in available treatment guidelines, combination antipsychotic prescribing (CAP) is a common practice in the treatment of schizophrenia. Patient characteristics may be associated with this type of treatment. A dataset (N = 363) derived from parallel randomised controlled trials was interrogated to identify factors associated with the receipt of CAP, and a logistic regression analysis was used to predict the occurrence of CAP. Significant predictors of CAP were longer illness, low global functioning score and high treatment adherence rating. Co-prescribed patients received a higher combined dose. © 2010 British Association for Psychopharmacology.

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KW - Augmentation

KW - Combination treatment

KW - Polypharmacy

KW - Prescribing

KW - Psychosis

KW - Schizophrenia

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Patient factors associated with receipt of combination antipsychotic drug therapy in the treatment of schizophrenia

Abstract

Keywords

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Research output

Non-evidence-based antipsychotic drug prescribing in the treatment of adult schizophrenia [PhD Thesis].

Cite this