TY - JOUR
T1 - PC.04 Can metabolomics be used to predict the risk of developing necrotising enterocolitis for babies born before 30 weeks' gestation?
AU - Wilcock, A
AU - Begley, P
AU - Hollywood, K
AU - Stevens, A
AU - Unwin, R
AU - Whatmore, A
AU - Victor, S
PY - 2014/6
Y1 - 2014/6
N2 - : Although necrotising enterocolitis (NEC) carries significant morbidity/mortality in preterm babies, it is poorly understood and its identification is hindered by the lack of a single diagnostic test. Metabolomics offers innovative opportunities for biomarker discovery and improving pathogenetic insight. We implemented a novel pilot study to determine if metabolomics could identify preterm babies at risk of NEC. To aid data interpretation, we also assessed the impact of gestational age and feeding on the metabolome. We collected serum samples from 12 pre-terms (
AB - : Although necrotising enterocolitis (NEC) carries significant morbidity/mortality in preterm babies, it is poorly understood and its identification is hindered by the lack of a single diagnostic test. Metabolomics offers innovative opportunities for biomarker discovery and improving pathogenetic insight. We implemented a novel pilot study to determine if metabolomics could identify preterm babies at risk of NEC. To aid data interpretation, we also assessed the impact of gestational age and feeding on the metabolome. We collected serum samples from 12 pre-terms (
U2 - 10.1136/archdischild-2014-306576.108
DO - 10.1136/archdischild-2014-306576.108
M3 - Article
C2 - 25021227
SN - 1468-2052
VL - 99 Suppl 1
JO - Archives of disease in childhood. Fetal and neonatal edition
JF - Archives of disease in childhood. Fetal and neonatal edition
ER -