Abstract
Recent reports have suggested that conjugation of peptides, proteins and antisense to short highly basic peptides, such as TAT, antennapedia and transportan, results in their rapid translocation into cells. Importantly, these conjugates have been shown to exert actions in a number of animal models suggesting their general utility for the determination of protein function in vitro and in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 587-594 |
| Number of pages | 7 |
| Journal | Current opinion in pharmacology |
| Volume | 2 |
| Issue number | 5 |
| Publication status | Published - 1 Oct 2002 |
Keywords
- Animals
- administration & dosage: Antisense Elements (Genetics)
- Cells
- Drug Delivery Systems
- Humans
- administration & dosage: Peptides
- administration & dosage: Proteins
- metabolism: Receptors, Drug
- drug effects: Signal Transduction
