“Perfecting” pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings

L Kaltschnee; A Kolmer; I Timari; V Schmidts; R W Adams; Mathias Nilsson; K E Kover; Gareth Morris; C M Thiele

doi:10.1039/c4cc04217d

“Perfecting” pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings

L Kaltschnee, A Kolmer, I Timari, V Schmidts, R W Adams, Mathias Nilsson, K E Kover, Gareth Morris, C M Thiele

Research output: Contribution to journal › Article › peer-review

Abstract

Fully homodecoupled HSQC spectra can be obtained through the use of a new pulse sequence element, "perfectBIRD". By way of illustration, we show that perfectBIRD decoupling allows one-bond residual dipolar couplings (RDCs), which provide important NMR restraints for structure elucidation, to be measured with outstanding precision, even in methylene groups.

Original language	English
Pages (from-to)	15702-15705
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	99
DOIs	https://doi.org/10.1039/c4cc04217d
Publication status	Published - 16 Oct 2014

Keywords

residual dipolar couplings
correlation nmr-spectroscopy
one-bond couplings
natural-abundance
spin-echo
spectra
resolution
rdcs
enhancement
sensitivity

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10.1039/c4cc04217d

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abstract = "Fully homodecoupled HSQC spectra can be obtained through the use of a new pulse sequence element, {"}perfectBIRD{"}. By way of illustration, we show that perfectBIRD decoupling allows one-bond residual dipolar couplings (RDCs), which provide important NMR restraints for structure elucidation, to be measured with outstanding precision, even in methylene groups.",

keywords = "residual dipolar couplings, correlation nmr-spectroscopy, one-bond couplings, natural-abundance, spin-echo, spectra, resolution, rdcs, enhancement, sensitivity",

author = "L Kaltschnee and A Kolmer and I Timari and V Schmidts and Adams, {R W} and Mathias Nilsson and Kover, {K E} and Gareth Morris and Thiele, {C M}",

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T1 - “Perfecting” pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings

AU - Kaltschnee, L

AU - Kolmer, A

AU - Timari, I

AU - Schmidts, V

AU - Adams, R W

AU - Nilsson, Mathias

AU - Kover, K E

AU - Morris, Gareth

AU - Thiele, C M

N1 - Au0ib Times Cited:0 Cited References Count:34

PY - 2014/10/16

Y1 - 2014/10/16

N2 - Fully homodecoupled HSQC spectra can be obtained through the use of a new pulse sequence element, "perfectBIRD". By way of illustration, we show that perfectBIRD decoupling allows one-bond residual dipolar couplings (RDCs), which provide important NMR restraints for structure elucidation, to be measured with outstanding precision, even in methylene groups.

AB - Fully homodecoupled HSQC spectra can be obtained through the use of a new pulse sequence element, "perfectBIRD". By way of illustration, we show that perfectBIRD decoupling allows one-bond residual dipolar couplings (RDCs), which provide important NMR restraints for structure elucidation, to be measured with outstanding precision, even in methylene groups.

KW - residual dipolar couplings

KW - correlation nmr-spectroscopy

KW - one-bond couplings

KW - natural-abundance

KW - spin-echo

KW - spectra

KW - resolution

KW - rdcs

KW - enhancement

KW - sensitivity

U2 - 10.1039/c4cc04217d

DO - 10.1039/c4cc04217d

M3 - Article

SN - 1364-548X

VL - 50

SP - 15702

EP - 15705

JO - Chemical Communications

JF - Chemical Communications

IS - 99

ER -

“Perfecting” pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings

Abstract

Keywords

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