Perinatal outcomes after maternal 2009/H1N1 infection: national cohort study.

Matthias Pierce, Jennifer J. Kurinczuk, Patsy Spark, Peter Brocklehurst, Marian Knight

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objectives: To follow up a UK national cohort of women admitted to hospital with confirmed 2009/H1N1 influenza in pregnancy in order to obtain a complete picture of pregnancy outcomes and estimate the risks of adverse fetal and infant outcomes. Design: National cohort study. Setting: 221 hospitals with obstetrician led maternity units in the UK. Participants: 256 women admitted to hospital with confirmed 2009/H1N1 in pregnancy during the second wave of pandemic infection between September 2009 and January 2010; 1220 pregnant women for comparison. Main outcome measures: Rates of stillbirth, perinatal mortality, and neonatal mortality; odds ratios for infected versus comparison women. Results: Perinatal mortality was higher in infants born to infected women (10 deaths among 256 infants; rate 39 (95% confidence interval 19 to 71) per 1000 total births) than in infants of uninfectedwomen (9 deaths among 1233 infants; rate 7 (3 to 13) per 1000 total births) (P
    Original languageEnglish
    Article numberd3214
    JournalB M J
    Volume342
    Issue number7811
    DOIs
    Publication statusPublished - 18 Jun 2011

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