Perioperative nutrition for the treatment of bladder cancer by radical cystectomy

Sorrel Burden, Hazel A Billson, Simon Lal, Kellie A Owen, Asif Muneer

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Radical cystectomy (RC) is the primary surgical treatment for muscle‐invasive urothelial carcinoma of the bladder. This major operation is typically associated with an extended hospital stay, a prolonged recovery period and potentially major complications. Nutritional interventions are beneficial in some people with other types of cancer and may be of value in this setting too.

To assess the effects of perioperative nutrition in people undergoing radical cystectomy for the treatment of bladder cancer.

Search methods
We performed a comprehensive search using multiple databases (Evidence Based Medicine Reviews, MEDLINE, Embase, AMED, CINAHL), trials registries, other sources of grey literature, and conference proceedings published up to 22 February 2019, with no restrictions on the language or status of publication.

Selection criteria
We included parallel‐group randomised controlled trials (RCTs) of adults undergoing RC for bladder cancer. The intervention was any perioperative nutrition support.

Data collection and analysis
Two review authors independently assessed studies for inclusion, extracted data, and assessed risk of bias and the quality of evidence using GRADE. Primary outcomes were postoperative complications at 90 days and length of hospital stay. The secondary outcome was mortality up to 90 days after surgery. When 90‐day outcome data were not available, we reported 30‐day data.
Original languageEnglish
JournalCochrane Database of Systematic Reviews
Early online date20 May 2019
Publication statusPublished - 2019


  • Perioperative
  • cystectomy [*methods]
  • length of stay
  • nutritional status
  • postoperative complications [*epidemology]
  • urinary bladder neoplasms [*surgery]
  • wound healing
  • Humans


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