Peripheral axon crush elevates transport of p75NTR in the central projection of sensory neurones of rats

Jean Dominique Delcroix, Jyoti Patel, Sharon Averill, David R. Tomlinson, John V. Priestley, Paul Fernyhough

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The effect of peripheral axon crush on the axonal transport of the neurotrophin receptors, p75NTR and trkA, was studied in dorsal roots of adult rats. Lumbar dorsal roots were crushed for 3-6 h to cause accumulation of p75NTR and trkA. Immunohistochemistry showed the presence of the NGF receptors in axons, indicating retrograde and anterograde axonal transport in the dorsal root. Western blots confirmed that the time course of accumulation of p75NTR was consistent with fast axonal transport. However, trkA accumulation was too low to indicate significant levels of axonal transport. Sciatic nerve crush induced a 2-fold increase (P
    Original languageEnglish
    Pages (from-to)181-185
    Number of pages4
    JournalNeuroscience letters
    Volume351
    Issue number3
    DOIs
    Publication statusPublished - 20 Nov 2003

    Keywords

    • Axonal transport
    • Dorsal root
    • Dorsal root ganglia
    • Nerve growth factor receptor
    • Neurotrophin
    • trkA

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