Peripheral channelopathies as targets for potassium channel openers

K. Lawson, M. J. Dunne

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Potassium channel openers (KCOs) are important tools that are often used to gain a greater understanding of K+ channels. Agents that can induce or maintain the opening of K+ channels also offer a therapeutic approach to controlling of cell excitability and offer a means of producing stability in biological systems. The pathogenesis of a broad range of peripheral disorders (e.g., LQT syndrome, hypokalemic periodic paralysis, hyperinsulinism in infancy and erectile dysfunction) are associated with dysfunctional K+ channels due to mutations in genes encoding channel proteins. The therapeutic potential of KCOs in peripheral K+ channelopathies is discussed. The identification of K+ channel subtype-specific openers offers discrete modulation of cellular systems creating a realistic therapeutic advance in the treatment of K+ channelopathies.
    Original languageEnglish
    Pages (from-to)1345-1359
    Number of pages14
    JournalExpert Opinion on Investigational Drugs
    Volume10
    Issue number7
    DOIs
    Publication statusPublished - 2001

    Keywords

    • HOPP
    • K+ channelopathies
    • LQT syndrome
    • Pancreatic β cells
    • Potassium channel openers
    • Urogenital

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