Abstract
Key Concepts:
- While traditionally viewed as little more than a simple lipid reserve, perivascular adipose tissue (PVAT) boasts an extensive biological arsenal which when mobilized can modulate vascular function.
- PVAT dysfunction in disease is associated with alteration to its secretory profile which can create a contractile and pro-inflammatory effect.
- PVAT dysfunction may be responsible for the comorbidity and mortality seen in various disease states, particularly the development of hypertension inobesity – now one of the world’s leading causes of mortality.
- Recently, it has been discovered that PVAT has a role as a sensor of coronary inflammation. This can be detectedusing a novel CT-derived metric, representing the first attempt at clinical translation of PVAT biology.
- While traditionally viewed as little more than a simple lipid reserve, perivascular adipose tissue (PVAT) boasts an extensive biological arsenal which when mobilized can modulate vascular function.
- PVAT dysfunction in disease is associated with alteration to its secretory profile which can create a contractile and pro-inflammatory effect.
- PVAT dysfunction may be responsible for the comorbidity and mortality seen in various disease states, particularly the development of hypertension inobesity – now one of the world’s leading causes of mortality.
- Recently, it has been discovered that PVAT has a role as a sensor of coronary inflammation. This can be detectedusing a novel CT-derived metric, representing the first attempt at clinical translation of PVAT biology.
| Original language | English |
|---|---|
| Title of host publication | Textbook of vascular medicine |
| Editors | Rhian M. Touyz, Christian Delles |
| Place of Publication | Cham, Switzerland |
| Publisher | Springer Nature |
| Chapter | 23 |
| Pages | 247-258 |
| Number of pages | 12 |
| ISBN (Electronic) | 9783030164812 |
| ISBN (Print) | 9783030164805, 9783030164836 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Perivascular adipose tissue
- Obesity
- Cardiovascular disease
- Hypertension
- Inflammation
