Perivascular adipose tissue

Saad Javed, Mariam Alakrawi, Adam S. Greenstein

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

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Abstract

Key Concepts:
- While traditionally viewed as little more than a simple lipid reserve, perivascular adipose tissue (PVAT) boasts an extensive biological arsenal which when mobilized can modulate vascular function.
- PVAT dysfunction in disease is associated with alteration to its secretory profile which can create a contractile and pro-inflammatory effect.
- PVAT dysfunction may be responsible for the comorbidity and mortality seen in various disease states, particularly the development of hypertension inobesity – now one of the world’s leading causes of mortality.
- Recently, it has been discovered that PVAT has a role as a sensor of coronary inflammation. This can be detectedusing a novel CT-derived metric, representing the first attempt at clinical translation of PVAT biology.
Original languageEnglish
Title of host publicationTextbook of vascular medicine
EditorsRhian M. Touyz, Christian Delles
Place of PublicationCham, Switzerland
PublisherSpringer Nature
Chapter23
Pages247-258
Number of pages12
ISBN (Electronic)9783030164812
ISBN (Print)9783030164805, 9783030164836
DOIs
Publication statusPublished - 2019

Keywords

  • Perivascular adipose tissue
  • Obesity
  • Cardiovascular disease
  • Hypertension
  • Inflammation

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