Pernicious anemia - Genetic insights

Siddharth Banka; Kate Ryan; Wendy Thomson; William G. Newman

doi:10.1016/j.autrev.2011.01.009

Pernicious anemia - Genetic insights

Siddharth Banka, Kate Ryan, Wendy Thomson, William G. Newman

Research output: Contribution to journal › Article › peer-review

Abstract

Pernicious anemia (PA) is a complex, autoimmune, multi-factorial disease. Rapid progress has been made in the understanding of susceptibility to a spectrum of other autoimmune diseases through genome wide association studies (GWAS). However, PA has been conspicuous by its absence from this work. Here, we examine the evidence that PA has a significant heritable component through epidemiological evidence and its co-occurrence with other autoimmune diseases. Further, we consider how knowledge of the genetic susceptibility to other autoimmune diseases may provide insight into the etiology of PA. © 2011 Elsevier B.V.

Original language	English
Pages (from-to)	455-459
Number of pages	4
Journal	Autoimmunity Reviews
Volume	10
Issue number	8
DOIs	https://doi.org/10.1016/j.autrev.2011.01.009
Publication status	Published - Jun 2011

Keywords

Atrophic body gastritis/Type A Autoimmune gastritis
Chronic gastritis
Helicobacter pylori
Intrinsic factor
Pernicious anemia
Vitamin B12/Cobalamin

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10.1016/j.autrev.2011.01.009

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title = "Pernicious anemia - Genetic insights",

abstract = "Pernicious anemia (PA) is a complex, autoimmune, multi-factorial disease. Rapid progress has been made in the understanding of susceptibility to a spectrum of other autoimmune diseases through genome wide association studies (GWAS). However, PA has been conspicuous by its absence from this work. Here, we examine the evidence that PA has a significant heritable component through epidemiological evidence and its co-occurrence with other autoimmune diseases. Further, we consider how knowledge of the genetic susceptibility to other autoimmune diseases may provide insight into the etiology of PA. {\textcopyright} 2011 Elsevier B.V.",

keywords = "Atrophic body gastritis/Type A Autoimmune gastritis, Chronic gastritis, Helicobacter pylori, Intrinsic factor, Pernicious anemia, Vitamin B12/Cobalamin",

author = "Siddharth Banka and Kate Ryan and Wendy Thomson and Newman, \{William G.\}",

year = "2011",

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doi = "10.1016/j.autrev.2011.01.009",

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volume = "10",

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T1 - Pernicious anemia - Genetic insights

AU - Banka, Siddharth

AU - Ryan, Kate

AU - Thomson, Wendy

AU - Newman, William G.

PY - 2011/6

Y1 - 2011/6

N2 - Pernicious anemia (PA) is a complex, autoimmune, multi-factorial disease. Rapid progress has been made in the understanding of susceptibility to a spectrum of other autoimmune diseases through genome wide association studies (GWAS). However, PA has been conspicuous by its absence from this work. Here, we examine the evidence that PA has a significant heritable component through epidemiological evidence and its co-occurrence with other autoimmune diseases. Further, we consider how knowledge of the genetic susceptibility to other autoimmune diseases may provide insight into the etiology of PA. © 2011 Elsevier B.V.

AB - Pernicious anemia (PA) is a complex, autoimmune, multi-factorial disease. Rapid progress has been made in the understanding of susceptibility to a spectrum of other autoimmune diseases through genome wide association studies (GWAS). However, PA has been conspicuous by its absence from this work. Here, we examine the evidence that PA has a significant heritable component through epidemiological evidence and its co-occurrence with other autoimmune diseases. Further, we consider how knowledge of the genetic susceptibility to other autoimmune diseases may provide insight into the etiology of PA. © 2011 Elsevier B.V.

KW - Atrophic body gastritis/Type A Autoimmune gastritis

KW - Chronic gastritis

KW - Helicobacter pylori

KW - Intrinsic factor

KW - Pernicious anemia

KW - Vitamin B12/Cobalamin

U2 - 10.1016/j.autrev.2011.01.009

DO - 10.1016/j.autrev.2011.01.009

M3 - Article

C2 - 21296191

SN - 1873-0183

VL - 10

SP - 455

EP - 459

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

IS - 8

ER -

Pernicious anemia - Genetic insights

Abstract

Keywords

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