Persistence of betapapillomavirus infections as a risk factor for actinic keratoses, precursor to cutaneous squamous cell carcinoma

Elsemieke I. Plasmeijer; Rachel E. Neale; Maurits N C De Koning; Wim G V Quint; Penelope McBride; Mariet C W Feltkamp; Adele C. Green

doi:10.1158/0008-5472.CAN-09-1186

Persistence of betapapillomavirus infections as a risk factor for actinic keratoses, precursor to cutaneous squamous cell carcinoma

Elsemieke I. Plasmeijer, Rachel E. Neale, Maurits N C De Koning, Wim G V Quint, Penelope McBride, Mariet C W Feltkamp, Adele C. Green

Research output: Contribution to journal › Article › peer-review

Abstract

Human papillomaviruses from the β genus (βPV) are a possible cause of cutaneous squamous cell carcinoma (SCC). We assessed the extent to which βPV infections persisted long-term in a subtropical Australian community and whether βPV persistence is positively associated with actinic keratoses, precursor for SCC. Eyebrowhairs were collected from 171 participants of the community-based Nambour Skin Cancer Study in 1996 and 2003. Hair samples were tested for the presence of DNA from 25 different βPV types and assessed in relation to actinic keratosis presence in 2007. In 1996, a total of 413 βPV infections were found in 73% of participants, increasing to 490 infections among 85% in 2003. Of the total βPV infections detected, 211 (30%) were found to persist. Age was significantly associated with βPV persistence: those ages >60 years had 1.5-fold (95% confidence interval, 1.1-1.9) increased risk of type-specific viral persistence than those ages

Original language	English
Pages (from-to)	8926-8931
Number of pages	5
Journal	Cancer Research
Volume	69
Issue number	23
DOIs	https://doi.org/10.1158/0008-5472.CAN-09-1186
Publication status	Published - 1 Dec 2009

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http://cancerres.aacrjournals.org/cgi/reprint/69/23/8926

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title = "Persistence of betapapillomavirus infections as a risk factor for actinic keratoses, precursor to cutaneous squamous cell carcinoma",

abstract = "Human papillomaviruses from the β genus (βPV) are a possible cause of cutaneous squamous cell carcinoma (SCC). We assessed the extent to which βPV infections persisted long-term in a subtropical Australian community and whether βPV persistence is positively associated with actinic keratoses, precursor for SCC. Eyebrowhairs were collected from 171 participants of the community-based Nambour Skin Cancer Study in 1996 and 2003. Hair samples were tested for the presence of DNA from 25 different βPV types and assessed in relation to actinic keratosis presence in 2007. In 1996, a total of 413 βPV infections were found in 73% of participants, increasing to 490 infections among 85% in 2003. Of the total βPV infections detected, 211 (30%) were found to persist. Age was significantly associated with βPV persistence: those ages >60 years had 1.5-fold (95% confidence interval, 1.1-1.9) increased risk of type-specific viral persistence than those ages",

author = "Plasmeijer, {Elsemieke I.} and Neale, {Rachel E.} and {De Koning}, {Maurits N C} and Quint, {Wim G V} and Penelope McBride and Feltkamp, {Mariet C W} and Green, {Adele C.}",

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doi = "10.1158/0008-5472.CAN-09-1186",

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T1 - Persistence of betapapillomavirus infections as a risk factor for actinic keratoses, precursor to cutaneous squamous cell carcinoma

AU - Plasmeijer, Elsemieke I.

AU - Neale, Rachel E.

AU - De Koning, Maurits N C

AU - Quint, Wim G V

AU - McBride, Penelope

AU - Feltkamp, Mariet C W

AU - Green, Adele C.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Human papillomaviruses from the β genus (βPV) are a possible cause of cutaneous squamous cell carcinoma (SCC). We assessed the extent to which βPV infections persisted long-term in a subtropical Australian community and whether βPV persistence is positively associated with actinic keratoses, precursor for SCC. Eyebrowhairs were collected from 171 participants of the community-based Nambour Skin Cancer Study in 1996 and 2003. Hair samples were tested for the presence of DNA from 25 different βPV types and assessed in relation to actinic keratosis presence in 2007. In 1996, a total of 413 βPV infections were found in 73% of participants, increasing to 490 infections among 85% in 2003. Of the total βPV infections detected, 211 (30%) were found to persist. Age was significantly associated with βPV persistence: those ages >60 years had 1.5-fold (95% confidence interval, 1.1-1.9) increased risk of type-specific viral persistence than those ages

AB - Human papillomaviruses from the β genus (βPV) are a possible cause of cutaneous squamous cell carcinoma (SCC). We assessed the extent to which βPV infections persisted long-term in a subtropical Australian community and whether βPV persistence is positively associated with actinic keratoses, precursor for SCC. Eyebrowhairs were collected from 171 participants of the community-based Nambour Skin Cancer Study in 1996 and 2003. Hair samples were tested for the presence of DNA from 25 different βPV types and assessed in relation to actinic keratosis presence in 2007. In 1996, a total of 413 βPV infections were found in 73% of participants, increasing to 490 infections among 85% in 2003. Of the total βPV infections detected, 211 (30%) were found to persist. Age was significantly associated with βPV persistence: those ages >60 years had 1.5-fold (95% confidence interval, 1.1-1.9) increased risk of type-specific viral persistence than those ages

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DO - 10.1158/0008-5472.CAN-09-1186

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JO - Cancer Research

JF - Cancer Research

IS - 23

ER -

Persistence of betapapillomavirus infections as a risk factor for actinic keratoses, precursor to cutaneous squamous cell carcinoma

Abstract

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