TY - JOUR
T1 - Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men: Results from the European male ageing study
AU - McBeth, John
AU - Tajar, Abdelouahid
AU - Macfarlane, Gary J.
AU - Bartfai, Gyorgy
AU - Boonen, Steven
AU - Bouillon, Roger
AU - Casanueva, Felipe
AU - Forti, Gianni
AU - Giwercman, Aleksander
AU - Han, Thang S.
AU - Kula, Krzysztof
AU - Lean, Michael E J
AU - Pendleton, Neil
AU - Punab, Margus
AU - Vanderschueren, Dirk
AU - Petrone, Luisa
AU - Cilotti, Antonio
AU - Borghs, Herman
AU - Slowikowska-Hilczer, Jolanta
AU - Walczak-Jedrzejowska, Renata
AU - Huhtaniemi, Ilpo
AU - Wu, Frederick
AU - Silman, Alan
AU - O'Neill, Terence
AU - Finn, Joseph
AU - Steer, Philip
AU - Lee, David
AU - Pye, Stephen
AU - Ocampo, Marta
AU - Lage, Mary
AU - Földesi, Imre
AU - Korrovitz, Paul
AU - Jiang, Min
PY - 2009/11
Y1 - 2009/11
N2 - Objective. To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men. Methods. The European Male Ageing Study (EMAS) is an 8-center population-based study of men aged 40-79 years recruited from population registers. A questionnaire asked about the presence and duration of musculoskeletal pain, from which subjects reporting CWP were identified. Subjects also had an interviewer-assisted questionnaire: levels of physical activity and mood were assessed, and height and weight were measured. IGF-1 and IGFBP-3 were assayed from a fasting blood sample. Logistic regression models were used to determine the association between IGF measures and CWP. Results were expressed as odds ratios or relative risk ratios. Results. A total of 3206 subjects provided full data. Of those, 1314 (39.0%) reported no pain in the past month and 278 (8.3%) reported pain that satisfied criteria for CWP. IGF-1 concentrations were similar among subjects who reported no pain and those with CWP: 131.5 mg/l and 128.4 mg/l, respectively. This was true also for IGFBP-3 (4.3 and 4.3 mg/l). Obesity was associated with low IGF-1 and a high IGFBP-3/IGF-1 ratio, indicating less bioavailable IGF-1, irrespective of pain status. This relationship persisted after adjustment for comorbidities, depression, smoking, alcohol consumption, and quality of life. Conclusion. Overall CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations. Hypofunctioning of the axis was noted among subjects who were obese and this was not specific to CWP. These data suggest that IGF-1 is unlikely to be etiologically important in relation to CWP, although the relationship with growth hormone remains to be elucidated. The Journal of Rheumatology Copyright © 2009. All rights reserved.
AB - Objective. To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men. Methods. The European Male Ageing Study (EMAS) is an 8-center population-based study of men aged 40-79 years recruited from population registers. A questionnaire asked about the presence and duration of musculoskeletal pain, from which subjects reporting CWP were identified. Subjects also had an interviewer-assisted questionnaire: levels of physical activity and mood were assessed, and height and weight were measured. IGF-1 and IGFBP-3 were assayed from a fasting blood sample. Logistic regression models were used to determine the association between IGF measures and CWP. Results were expressed as odds ratios or relative risk ratios. Results. A total of 3206 subjects provided full data. Of those, 1314 (39.0%) reported no pain in the past month and 278 (8.3%) reported pain that satisfied criteria for CWP. IGF-1 concentrations were similar among subjects who reported no pain and those with CWP: 131.5 mg/l and 128.4 mg/l, respectively. This was true also for IGFBP-3 (4.3 and 4.3 mg/l). Obesity was associated with low IGF-1 and a high IGFBP-3/IGF-1 ratio, indicating less bioavailable IGF-1, irrespective of pain status. This relationship persisted after adjustment for comorbidities, depression, smoking, alcohol consumption, and quality of life. Conclusion. Overall CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations. Hypofunctioning of the axis was noted among subjects who were obese and this was not specific to CWP. These data suggest that IGF-1 is unlikely to be etiologically important in relation to CWP, although the relationship with growth hormone remains to be elucidated. The Journal of Rheumatology Copyright © 2009. All rights reserved.
KW - Chronic pain
KW - Epidemiology
KW - Insulin-like growth factor binding protein-3
KW - Insulin-like growth factor-1
KW - Men
KW - Population study
U2 - 10.3899/jrheum.090113
DO - 10.3899/jrheum.090113
M3 - Article
C2 - 19833751
SN - 1499-2752
VL - 36
SP - 2523
EP - 2530
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 11
ER -
