pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor

K. Matsuda; A. M. Hosie; S. D. Buckingham; M. D. Squire; H. A. Baylis; D. B. Sattelle

doi:10.1016/S0006-8993(96)00998-5

pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor

K. Matsuda, A. M. Hosie, S. D. Buckingham, M. D. Squire, H. A. Baylis, D. B. Sattelle

Research output: Contribution to journal › Article › peer-review

Abstract

The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.

Original language	English
Pages (from-to)	335-338
Number of pages	3
Journal	Brain research
Volume	739
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(96)00998-5
Publication status	Published - 11 Nov 1996

Keywords

Drosophila melanogaster
GABA receptor
RDL (resistant to dieldrin) subunit
THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol)
ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid)

Access to Document

10.1016/S0006-8993(96)00998-5

Cite this

@article{bf97c61f252b43f780f0f665da0d2a42,

title = "pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor",

abstract = "The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.",

keywords = "Drosophila melanogaster, GABA receptor, RDL (resistant to dieldrin) subunit, THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol), ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid)",

author = "K. Matsuda and Hosie, {A. M.} and Buckingham, {S. D.} and Squire, {M. D.} and Baylis, {H. A.} and Sattelle, {D. B.}",

year = "1996",

month = nov,

day = "11",

doi = "10.1016/S0006-8993(96)00998-5",

language = "English",

volume = "739",

pages = "335--338",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier BV",

number = "1-2",

}

TY - JOUR

T1 - pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor

AU - Matsuda, K.

AU - Hosie, A. M.

AU - Buckingham, S. D.

AU - Squire, M. D.

AU - Baylis, H. A.

AU - Sattelle, D. B.

PY - 1996/11/11

Y1 - 1996/11/11

N2 - The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.

AB - The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.

KW - Drosophila melanogaster

KW - GABA receptor

KW - RDL (resistant to dieldrin) subunit

KW - THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol)

KW - ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid)

U2 - 10.1016/S0006-8993(96)00998-5

DO - 10.1016/S0006-8993(96)00998-5

M3 - Article

C2 - 8955956

SN - 0006-8993

VL - 739

SP - 335

EP - 338

JO - Brain research

JF - Brain research

IS - 1-2

ER -

pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor

Abstract

Keywords

Access to Document

Fingerprint

Cite this