pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor

K. Matsuda; A. M. Hosie; S. D. Buckingham; M. D. Squire; H. A. Baylis; D. B. Sattelle

doi:10.1016/S0006-8993(96)00998-5

pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor

K. Matsuda
, A. M. Hosie
, S. D. Buckingham
, M. D. Squire
, H. A. Baylis
, D. B. Sattelle

Research output: Contribution to journal › Article › peer-review

Abstract

The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.

Original language	English
Pages (from-to)	335-338
Number of pages	3
Journal	Brain research
Volume	739
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(96)00998-5
Publication status	Published - 11 Nov 1996

Keywords

Drosophila melanogaster
GABA receptor
RDL (resistant to dieldrin) subunit
THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol)
ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid)

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10.1016/S0006-8993(96)00998-5

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title = "pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor",

abstract = "The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.",

keywords = "Drosophila melanogaster, GABA receptor, RDL (resistant to dieldrin) subunit, THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol), ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid)",

author = "K. Matsuda and Hosie, \{A. M.\} and Buckingham, \{S. D.\} and Squire, \{M. D.\} and Baylis, \{H. A.\} and Sattelle, \{D. B.\}",

year = "1996",

month = nov,

day = "11",

doi = "10.1016/S0006-8993(96)00998-5",

language = "English",

volume = "739",

pages = "335--338",

journal = "Brain research",

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TY - JOUR

T1 - pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor

AU - Matsuda, K.

AU - Hosie, A. M.

AU - Buckingham, S. D.

AU - Squire, M. D.

AU - Baylis, H. A.

AU - Sattelle, D. B.

PY - 1996/11/11

Y1 - 1996/11/11

N2 - The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.

AB - The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.

KW - Drosophila melanogaster

KW - GABA receptor

KW - RDL (resistant to dieldrin) subunit

KW - THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol)

KW - ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid)

U2 - 10.1016/S0006-8993(96)00998-5

DO - 10.1016/S0006-8993(96)00998-5

M3 - Article

C2 - 8955956

SN - 0006-8993

VL - 739

SP - 335

EP - 338

JO - Brain research

JF - Brain research

IS - 1-2

ER -

pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor

Abstract

Keywords

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