Pharmaceutical compounds studied using NEXAFS

Alastair Booth, A. Murray Booth, Simon Braun, Tom Lonsbourough, John Purton, Sunil Patel, Sven L M Schroeder

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Total Electron Yield (TEY) oxygen K-edge NEXAFS detects the presence of strongly adsorbed water molecules on poloxamer-coated pharmaceutical actives, which provides a useful spectroscopic indicator for bioavailability. The results are supported by complementary XPS measurements. Carbon K-edge spectra obtained in a high-pressure NEXAFS cell were used in situ to establish how a polymer coating spread on a drug surface by using humidity induced dispersion of the coating. Finally, we demonstrate how combined Carbon and Oxygen K-edge measurements can be used to characterize amorphous surface layers on micronised crystals of a drug compound. © 2007 American Institute of Physics.
    Original languageEnglish
    Pages (from-to)325-327
    Number of pages2
    JournalAIP Conference Proceedings
    Volume882
    DOIs
    Publication statusPublished - 2007

    Keywords

    • NEXAFS
    • Pharmaceuticals

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