Pharmaceutical compounds studied using NEXAFS

Alastair Booth; A. Murray Booth; Simon Braun; Tom Lonsbourough; John Purton; Sunil Patel; Sven L M Schroeder

doi:10.1063/1.2644514

Pharmaceutical compounds studied using NEXAFS

Alastair Booth, A. Murray Booth, Simon Braun, Tom Lonsbourough, John Purton, Sunil Patel, Sven L M Schroeder

Research output: Contribution to journal › Article › peer-review

Abstract

Total Electron Yield (TEY) oxygen K-edge NEXAFS detects the presence of strongly adsorbed water molecules on poloxamer-coated pharmaceutical actives, which provides a useful spectroscopic indicator for bioavailability. The results are supported by complementary XPS measurements. Carbon K-edge spectra obtained in a high-pressure NEXAFS cell were used in situ to establish how a polymer coating spread on a drug surface by using humidity induced dispersion of the coating. Finally, we demonstrate how combined Carbon and Oxygen K-edge measurements can be used to characterize amorphous surface layers on micronised crystals of a drug compound. © 2007 American Institute of Physics.

Original language	English
Pages (from-to)	325-327
Number of pages	2
Journal	AIP Conference Proceedings
Volume	882
DOIs	https://doi.org/10.1063/1.2644514
Publication status	Published - 2007

Keywords

NEXAFS
Pharmaceuticals

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10.1063/1.2644514

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title = "Pharmaceutical compounds studied using NEXAFS",

abstract = "Total Electron Yield (TEY) oxygen K-edge NEXAFS detects the presence of strongly adsorbed water molecules on poloxamer-coated pharmaceutical actives, which provides a useful spectroscopic indicator for bioavailability. The results are supported by complementary XPS measurements. Carbon K-edge spectra obtained in a high-pressure NEXAFS cell were used in situ to establish how a polymer coating spread on a drug surface by using humidity induced dispersion of the coating. Finally, we demonstrate how combined Carbon and Oxygen K-edge measurements can be used to characterize amorphous surface layers on micronised crystals of a drug compound. {\textcopyright} 2007 American Institute of Physics.",

keywords = "NEXAFS, Pharmaceuticals",

author = "Alastair Booth and {Murray Booth}, A. and Simon Braun and Tom Lonsbourough and John Purton and Sunil Patel and Schroeder, {Sven L M}",

year = "2007",

doi = "10.1063/1.2644514",

language = "English",

volume = "882",

pages = "325--327",

journal = "AIP Conference Proceedings",

issn = "0094-243X",

publisher = "American Institute of Physics",

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TY - JOUR

T1 - Pharmaceutical compounds studied using NEXAFS

AU - Booth, Alastair

AU - Murray Booth, A.

AU - Braun, Simon

AU - Lonsbourough, Tom

AU - Purton, John

AU - Patel, Sunil

AU - Schroeder, Sven L M

PY - 2007

Y1 - 2007

N2 - Total Electron Yield (TEY) oxygen K-edge NEXAFS detects the presence of strongly adsorbed water molecules on poloxamer-coated pharmaceutical actives, which provides a useful spectroscopic indicator for bioavailability. The results are supported by complementary XPS measurements. Carbon K-edge spectra obtained in a high-pressure NEXAFS cell were used in situ to establish how a polymer coating spread on a drug surface by using humidity induced dispersion of the coating. Finally, we demonstrate how combined Carbon and Oxygen K-edge measurements can be used to characterize amorphous surface layers on micronised crystals of a drug compound. © 2007 American Institute of Physics.

AB - Total Electron Yield (TEY) oxygen K-edge NEXAFS detects the presence of strongly adsorbed water molecules on poloxamer-coated pharmaceutical actives, which provides a useful spectroscopic indicator for bioavailability. The results are supported by complementary XPS measurements. Carbon K-edge spectra obtained in a high-pressure NEXAFS cell were used in situ to establish how a polymer coating spread on a drug surface by using humidity induced dispersion of the coating. Finally, we demonstrate how combined Carbon and Oxygen K-edge measurements can be used to characterize amorphous surface layers on micronised crystals of a drug compound. © 2007 American Institute of Physics.

KW - NEXAFS

KW - Pharmaceuticals

U2 - 10.1063/1.2644514

DO - 10.1063/1.2644514

M3 - Article

VL - 882

SP - 325

EP - 327

JO - AIP Conference Proceedings

JF - AIP Conference Proceedings

SN - 0094-243X

ER -

Pharmaceutical compounds studied using NEXAFS

Abstract

Keywords

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