Pharmaceutical hydrates under ambient conditions from high-pressure seeds: A case study of GABA monohydrate

Francesca P A Fabbiani*, Gernot Buth, Demetrius C. Levendis, Aurora J. Cruz-Cabeza

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4-0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.

Original languageEnglish
Pages (from-to)1817-1819
Number of pages3
JournalChemical Communications
Volume50
Issue number15
DOIs
Publication statusPublished - 21 Feb 2014

Fingerprint

Dive into the research topics of 'Pharmaceutical hydrates under ambient conditions from high-pressure seeds: A case study of GABA monohydrate'. Together they form a unique fingerprint.

Cite this