Pharmacogenetics of TNFi Response in Rheumatoid Arthritis Utilising the Two-Component Disease Activity Score

S. S. A. Gilani; Nisha Nair; Darren Plant; Kimme Hyrich; A. W. Morgan; Andrew Morris; A. G. Wilson; J. D. Isaacs; Anne Barton; James Bluett

Pharmacogenetics of TNFi Response in Rheumatoid Arthritis Utilising the Two-Component Disease Activity Score

S. S. A. Gilani, Nisha Nair, Darren Plant, Kimme Hyrich, A. W. Morgan, Andrew Morris, A. G. Wilson, J. D. Isaacs, Anne Barton, James Bluett

Division of Musculoskeletal & Dermatological Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: TNF inhibitor (TNFi) drugs are a treatment option for rheumatoid arthritis (RA), but response is not universal. Response is typically measured using the composite 4-component (4C) disease activity score 28 (DAS28) which contains more subjective measures. This study used a validated 2-component (2C) DAS28 score to determine whether SNPs associated with response were replicated in a UK population. Materials & Methods: A literature review identified TNFi response SNPs. Linear regression was conducted to replicate associations with 4C or 2C-DAS28 response. Results: 18 independent SNPs were analysed in 1828 patients. One and four associations with 4C and 2C-DAS28 response respectively were identified (P<0.05). Conclusion: Further genetic associations were replicated using the 2C-DAS28 which may reflect the objective nature of 2C-DAS28.

Original language	English
Journal	Pharmacogenomics
Publication status	Accepted/In press - 17 Aug 2020

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@article{4c31f8804ff5489c8f0e806e580cc450,

title = "Pharmacogenetics of TNFi Response in Rheumatoid Arthritis Utilising the Two-Component Disease Activity Score",

abstract = "Aim: TNF inhibitor (TNFi) drugs are a treatment option for rheumatoid arthritis (RA), but response is not universal. Response is typically measured using the composite 4-component (4C) disease activity score 28 (DAS28) which contains more subjective measures. This study used a validated 2-component (2C) DAS28 score to determine whether SNPs associated with response were replicated in a UK population. Materials & Methods: A literature review identified TNFi response SNPs. Linear regression was conducted to replicate associations with 4C or 2C-DAS28 response. Results: 18 independent SNPs were analysed in 1828 patients. One and four associations with 4C and 2C-DAS28 response respectively were identified (P<0.05). Conclusion: Further genetic associations were replicated using the 2C-DAS28 which may reflect the objective nature of 2C-DAS28. ",

author = "Gilani, {S. S. A.} and Nisha Nair and Darren Plant and Kimme Hyrich and Morgan, {A. W.} and Andrew Morris and Wilson, {A. G.} and Isaacs, {J. D.} and Anne Barton and James Bluett",

year = "2020",

month = aug,

day = "17",

language = "English",

journal = "Pharmacogenomics",

issn = "1744-8042",

publisher = "Future Medicine ",

}

TY - JOUR

T1 - Pharmacogenetics of TNFi Response in Rheumatoid Arthritis Utilising the Two-Component Disease Activity Score

AU - Gilani, S. S. A.

AU - Nair, Nisha

AU - Plant, Darren

AU - Hyrich, Kimme

AU - Morgan, A. W.

AU - Morris, Andrew

AU - Wilson, A. G.

AU - Isaacs, J. D.

AU - Barton, Anne

AU - Bluett, James

PY - 2020/8/17

Y1 - 2020/8/17

N2 - Aim: TNF inhibitor (TNFi) drugs are a treatment option for rheumatoid arthritis (RA), but response is not universal. Response is typically measured using the composite 4-component (4C) disease activity score 28 (DAS28) which contains more subjective measures. This study used a validated 2-component (2C) DAS28 score to determine whether SNPs associated with response were replicated in a UK population. Materials & Methods: A literature review identified TNFi response SNPs. Linear regression was conducted to replicate associations with 4C or 2C-DAS28 response. Results: 18 independent SNPs were analysed in 1828 patients. One and four associations with 4C and 2C-DAS28 response respectively were identified (P<0.05). Conclusion: Further genetic associations were replicated using the 2C-DAS28 which may reflect the objective nature of 2C-DAS28.

AB - Aim: TNF inhibitor (TNFi) drugs are a treatment option for rheumatoid arthritis (RA), but response is not universal. Response is typically measured using the composite 4-component (4C) disease activity score 28 (DAS28) which contains more subjective measures. This study used a validated 2-component (2C) DAS28 score to determine whether SNPs associated with response were replicated in a UK population. Materials & Methods: A literature review identified TNFi response SNPs. Linear regression was conducted to replicate associations with 4C or 2C-DAS28 response. Results: 18 independent SNPs were analysed in 1828 patients. One and four associations with 4C and 2C-DAS28 response respectively were identified (P<0.05). Conclusion: Further genetic associations were replicated using the 2C-DAS28 which may reflect the objective nature of 2C-DAS28.

M3 - Article

SN - 1744-8042

JO - Pharmacogenomics

JF - Pharmacogenomics

ER -

Pharmacogenetics of TNFi Response in Rheumatoid Arthritis Utilising the Two-Component Disease Activity Score

Abstract

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