Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature

Adam Stevens; Reena Perchard; Terence Garner; Peter Clayton; Philip Murray

Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature

Adam Stevens, Reena Perchard, Terence Garner, Peter Clayton, Philip Murray

Division of Developmental Biology & Medicine (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

We present current knowledge concerning the pharmacogenomics of growth hormone therapy in children with short stature. We consider the evidence now emerging for the polygenic nature of response to recombinant human growth hormone (r-hGH). These data are related predominantly to the use of transcriptomic data for prediction. The impact of the complex interactions of developmental phenotype over childhood on response to r-hGH are discussed. Finally, the issues that need to be addressed in order to develop a clinical test are described.

Original language	English
Journal	Reviews in Endocrine and Metabolic Disorders
Publication status	Accepted/In press - 5 Mar 2021

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title = "Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature",

abstract = "We present current knowledge concerning the pharmacogenomics of growth hormone therapy in children with short stature. We consider the evidence now emerging for the polygenic nature of response to recombinant human growth hormone (r-hGH). These data are related predominantly to the use of transcriptomic data for prediction. The impact of the complex interactions of developmental phenotype over childhood on response to r-hGH are discussed. Finally, the issues that need to be addressed in order to develop a clinical test are described.",

author = "Adam Stevens and Reena Perchard and Terence Garner and Peter Clayton and Philip Murray",

year = "2021",

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language = "English",

journal = "Reviews in Endocrine and Metabolic Disorders",

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T1 - Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature

AU - Stevens, Adam

AU - Perchard, Reena

AU - Garner, Terence

AU - Clayton, Peter

AU - Murray, Philip

PY - 2021/3/5

Y1 - 2021/3/5

N2 - We present current knowledge concerning the pharmacogenomics of growth hormone therapy in children with short stature. We consider the evidence now emerging for the polygenic nature of response to recombinant human growth hormone (r-hGH). These data are related predominantly to the use of transcriptomic data for prediction. The impact of the complex interactions of developmental phenotype over childhood on response to r-hGH are discussed. Finally, the issues that need to be addressed in order to develop a clinical test are described.

AB - We present current knowledge concerning the pharmacogenomics of growth hormone therapy in children with short stature. We consider the evidence now emerging for the polygenic nature of response to recombinant human growth hormone (r-hGH). These data are related predominantly to the use of transcriptomic data for prediction. The impact of the complex interactions of developmental phenotype over childhood on response to r-hGH are discussed. Finally, the issues that need to be addressed in order to develop a clinical test are described.

M3 - Article

SN - 1389-9155

JO - Reviews in Endocrine and Metabolic Disorders

JF - Reviews in Endocrine and Metabolic Disorders

ER -

Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature

Abstract

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