Pharmacological properties of axonal sodium channels in the cockroach Periplaneta americana L. II. Slowing of sodium current turn-off by Condylactis toxin.

M. Pelhate, B. Hue, D. B. Sattelle

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Condylactis toxin induces a prolonged falling phase in action potentials recorded from giant axons of the cockroach Periplaneta americana L. A distinct plateau potential can be recorded in the presence of Condylactis toxin at concentrations of 0.5 mg/ml and above. In cockroach axons, voltage-clamp experiments show that Condylactis toxin acts primarily by slowing the sodium current turn-off without affecting either the time-course of the sodium conductance increase or the peak amplitude of the transient sodium current.
    Original languageEnglish
    Pages (from-to)49-58
    Number of pages9
    JournalJournal of Experimental Biology
    Volume83
    Publication statusPublished - Dec 1979

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