Phenotype Standardization for Statin-Induced Myotoxicity

A. Alfirevic; D. Neely; J. Armitage; H. Chinoy; R. G. Cooper; R. Laaksonen; D. F. Carr; K. M. Bloch; J. Fahy; A. Hanson; Q. Y. Yue; M. Wadelius; A. H. Maitland-van Der Zee; D. Voora; B. M. Psaty; C. N A Palmer; M. Pirmohamed

doi:10.1038/clpt.2014.121

Phenotype Standardization for Statin-Induced Myotoxicity

A. Alfirevic, D. Neely, J. Armitage, H. Chinoy, R. G. Cooper, R. Laaksonen, D. F. Carr, K. M. Bloch, J. Fahy, A. Hanson, Q. Y. Yue, M. Wadelius, A. H. Maitland-van Der Zee, D. Voora, B. M. Psaty, C. N A Palmer, M. Pirmohamed

Research output: Contribution to journal › Article › peer-review

Abstract

Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.Clinical Pharmacology and Therapeutics (2014); advance online publication 02 July 2014. doi:10.1038/clpt.2014.121.

Original language	English
Journal	Clinical Pharmacology and Therapeutics
DOIs	https://doi.org/10.1038/clpt.2014.121
Publication status	Published - 4 Jun 2014

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Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., Carr, D. F., Bloch, K. M., Fahy, J., Hanson, A., Yue, Q. Y., Wadelius, M., Maitland-van Der Zee, A. H., Voora, D., Psaty, B. M., Palmer, C. N. A., & Pirmohamed, M. (2014). Phenotype Standardization for Statin-Induced Myotoxicity. Clinical Pharmacology and Therapeutics. https://doi.org/10.1038/clpt.2014.121

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title = "Phenotype Standardization for Statin-Induced Myotoxicity",

abstract = "Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.Clinical Pharmacology and Therapeutics (2014); advance online publication 02 July 2014. doi:10.1038/clpt.2014.121.",

author = "A. Alfirevic and D. Neely and J. Armitage and H. Chinoy and Cooper, {R. G.} and R. Laaksonen and Carr, {D. F.} and Bloch, {K. M.} and J. Fahy and A. Hanson and Yue, {Q. Y.} and M. Wadelius and {Maitland-van Der Zee}, {A. H.} and D. Voora and Psaty, {B. M.} and Palmer, {C. N A} and M. Pirmohamed",

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doi = "10.1038/clpt.2014.121",

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T1 - Phenotype Standardization for Statin-Induced Myotoxicity

AU - Alfirevic, A.

AU - Neely, D.

AU - Armitage, J.

AU - Chinoy, H.

AU - Cooper, R. G.

AU - Laaksonen, R.

AU - Carr, D. F.

AU - Bloch, K. M.

AU - Fahy, J.

AU - Hanson, A.

AU - Yue, Q. Y.

AU - Wadelius, M.

AU - Maitland-van Der Zee, A. H.

AU - Voora, D.

AU - Psaty, B. M.

AU - Palmer, C. N A

AU - Pirmohamed, M.

PY - 2014/6/4

Y1 - 2014/6/4

N2 - Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.Clinical Pharmacology and Therapeutics (2014); advance online publication 02 July 2014. doi:10.1038/clpt.2014.121.

AB - Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.Clinical Pharmacology and Therapeutics (2014); advance online publication 02 July 2014. doi:10.1038/clpt.2014.121.

U2 - 10.1038/clpt.2014.121

DO - 10.1038/clpt.2014.121

M3 - Article

C2 - 24897241

SN - 0009-9236

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

ER -

Phenotype Standardization for Statin-Induced Myotoxicity

Abstract

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