Photodynamic activity of Sn(IV) meso-tetraacenaphthylporphyrin and its methyl-β-cyclodextrin inclusion complexes on MCF-7 breast cancer cells

Nthabeleng Molupe; Balaji Babu; Earl Prinsloo; Abdessamad Kaassis; Katharina Edkins; John Mack; Tebello Nyokong

doi:10.1142/S1088424619501633

Photodynamic activity of Sn(IV) meso-tetraacenaphthylporphyrin and its methyl-β-cyclodextrin inclusion complexes on MCF-7 breast cancer cells

Nthabeleng Molupe, Balaji Babu, Earl Prinsloo, Abdessamad Kaassis, Katharina Edkins, John Mack, Tebello Nyokong

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

A novel Sn(IV) meso-tetraacenaphthylporphyrin (SnTAcP) has been synthesized and characterized. SnTAcP was complexed with methyl-β-CD (mβ-CD), a nanocarrier that enhances water solubility, and the complexes were evaluated as PDT agents using MCF-7 breast cancer cells. A relatively low singlet oxygen quantum yield value of 0.36 was obtained in DMF, and the lowest energy Q band lies at 608 nm on the edge of the therapeutic window. SnTAcP was found to be non-toxic in the dark and phototoxic towards MCF-7 breast cancer cells with a half-maximal inhibitory concentration (IC50) value of 11 ± 1.1 µg.mL−1 after 30 min of irradiation with a 625 nm Thorlabs LED that provides a dose of 432 J.cm−2. A higher IC50 value of 21 ± 1.1 µg.mL−1 was obtained for the mβ-CD inclusion complex of SnTAcP.

Original language	English
Journal	Journal of Porphyrins and Phthalocyanines
Volume	23
Issue number	11n12
DOIs	https://doi.org/10.1142/S1088424619501633
Publication status	Published - 16 Oct 2019

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@article{85e9a0acf5ab4bba861d539371f605c9,

title = "Photodynamic activity of Sn(IV) meso-tetraacenaphthylporphyrin and its methyl-β-cyclodextrin inclusion complexes on MCF-7 breast cancer cells",

abstract = "A novel Sn(IV) meso-tetraacenaphthylporphyrin (SnTAcP) has been synthesized and characterized. SnTAcP was complexed with methyl-β-CD (mβ-CD), a nanocarrier that enhances water solubility, and the complexes were evaluated as PDT agents using MCF-7 breast cancer cells. A relatively low singlet oxygen quantum yield value of 0.36 was obtained in DMF, and the lowest energy Q band lies at 608 nm on the edge of the therapeutic window. SnTAcP was found to be non-toxic in the dark and phototoxic towards MCF-7 breast cancer cells with a half-maximal inhibitory concentration (IC50) value of 11 ± 1.1 µg.mL−1 after 30 min of irradiation with a 625 nm Thorlabs LED that provides a dose of 432 J.cm−2. A higher IC50 value of 21 ± 1.1 µg.mL−1 was obtained for the mβ-CD inclusion complex of SnTAcP.",

author = "Nthabeleng Molupe and Balaji Babu and Earl Prinsloo and Abdessamad Kaassis and Katharina Edkins and John Mack and Tebello Nyokong",

year = "2019",

month = oct,

day = "16",

doi = "10.1142/S1088424619501633",

language = "English",

volume = "23",

journal = "Journal of Porphyrins and Phthalocyanines",

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TY - JOUR

T1 - Photodynamic activity of Sn(IV) meso-tetraacenaphthylporphyrin and its methyl-β-cyclodextrin inclusion complexes on MCF-7 breast cancer cells

AU - Molupe, Nthabeleng

AU - Babu, Balaji

AU - Prinsloo, Earl

AU - Kaassis, Abdessamad

AU - Edkins, Katharina

AU - Mack, John

AU - Nyokong, Tebello

PY - 2019/10/16

Y1 - 2019/10/16

N2 - A novel Sn(IV) meso-tetraacenaphthylporphyrin (SnTAcP) has been synthesized and characterized. SnTAcP was complexed with methyl-β-CD (mβ-CD), a nanocarrier that enhances water solubility, and the complexes were evaluated as PDT agents using MCF-7 breast cancer cells. A relatively low singlet oxygen quantum yield value of 0.36 was obtained in DMF, and the lowest energy Q band lies at 608 nm on the edge of the therapeutic window. SnTAcP was found to be non-toxic in the dark and phototoxic towards MCF-7 breast cancer cells with a half-maximal inhibitory concentration (IC50) value of 11 ± 1.1 µg.mL−1 after 30 min of irradiation with a 625 nm Thorlabs LED that provides a dose of 432 J.cm−2. A higher IC50 value of 21 ± 1.1 µg.mL−1 was obtained for the mβ-CD inclusion complex of SnTAcP.

AB - A novel Sn(IV) meso-tetraacenaphthylporphyrin (SnTAcP) has been synthesized and characterized. SnTAcP was complexed with methyl-β-CD (mβ-CD), a nanocarrier that enhances water solubility, and the complexes were evaluated as PDT agents using MCF-7 breast cancer cells. A relatively low singlet oxygen quantum yield value of 0.36 was obtained in DMF, and the lowest energy Q band lies at 608 nm on the edge of the therapeutic window. SnTAcP was found to be non-toxic in the dark and phototoxic towards MCF-7 breast cancer cells with a half-maximal inhibitory concentration (IC50) value of 11 ± 1.1 µg.mL−1 after 30 min of irradiation with a 625 nm Thorlabs LED that provides a dose of 432 J.cm−2. A higher IC50 value of 21 ± 1.1 µg.mL−1 was obtained for the mβ-CD inclusion complex of SnTAcP.

U2 - 10.1142/S1088424619501633

DO - 10.1142/S1088424619501633

M3 - Article

SN - 1088-4246

VL - 23

JO - Journal of Porphyrins and Phthalocyanines

JF - Journal of Porphyrins and Phthalocyanines

IS - 11n12

ER -

Photodynamic activity of Sn(IV) meso-tetraacenaphthylporphyrin and its methyl-β-cyclodextrin inclusion complexes on MCF-7 breast cancer cells

Abstract

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